The most common symptom of pancreatic cancer is abdominal pain, typically pain in the upper abdomen. Jaundice is also common, especially in cancers of the head of the pancreas, where it is the most frequent clinical manifestation. Upon physical examination, some patients may have a palpable mass in the upper abdomen. Other common symptoms include gastrointestinal issues, such as nausea, vomiting, a feeling of fullness after eating, and a decrease in appetite. These are some of the symptoms related to the digestive tract.