Differentiation between Duodenal Ulcer and Gastric Ulcer

Written by Si Li Li

Gastroenterology

Updated on February 01, 2025

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Duodenal ulcers and gastric ulcers primarily differ in their locations: duodenal ulcers occur in the mucosa of the duodenum, whereas gastric ulcers are found in the gastric mucosa. Secondly, the characteristics of upper abdominal pain differ between the two. Pain from duodenal ulcers typically worsens when hungry and lessens after eating, whereas with gastric ulcers, pain intensifies after eating and decreases when hungry. Thirdly, the prognosis differs; gastric ulcers have a certain potential for malignant transformation, and some large ulcers may already be gastric cancer, while duodenal ulcers rarely develop into malignant tumors. It is advisable to undergo active treatment after a clear diagnosis.

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Written by Wu Hai Wu

Gastroenterology

39sec

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What position should be taken for duodenal ulcer hematemesis?

Patients with duodenal ulcers, if vomiting blood occurs, are advised to slightly elevate their lower limbs, position their heads lower, and lie on their side. Because when patients with duodenal ulcers vomit blood, it indicates a relatively large amount of bleeding. Elevating the lower limbs slightly can effectively promote the return of blood from the lower limbs, ensuring the blood supply to vital organs, and lying on the side helps prevent the possibility of choking following vomiting. Once vomiting blood due to a duodenal ulcer occurs, an urgent gastroscopy is required, and hemostatic treatment should be carried out under gastroscopy.

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Written by Si Li Li

Gastroenterology

1min 4sec

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What will happen if you drink alcohol with a duodenal bulb ulcer?

Common symptoms of duodenal bulb ulcers include stomach pain, bloating, belching, acid reflux, nausea, and vomiting. A gastroscopy can reveal defects in the duodenal mucosa, which can be diagnosed as duodenal ulcers. Drinking alcohol can irritate the gastric mucosa as well as the duodenal mucosa. If there is an ulcer in the duodenal bulb and alcohol is consumed, it can exacerbate the ulcer, causing the ulcerated area to enlarge and more severe symptoms to appear. Therefore, drinking alcohol can lead to the worsening of duodenal ulcers. Thus, individuals with gastric diseases or peptic ulcers must abstain from alcohol, as it can aggravate the existing condition. If a duodenal ulcer worsens, penetrating the serosal or basal layer, it may lead to perforation. In such cases, emergency surgery is required for treatment. Hence, it is crucial for those with duodenal ulcers to avoid alcohol.

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Written by Jiang Guo Ming

Gastroenterology

1min 1sec

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Can duodenal ulcers be cured?

Duodenal bulb ulcers are definitely treatable. Treatment is mainly through medication, with the specific approach depending on the presence of Helicobacter pylori infection. If there is no Helicobacter pylori infection, treatment primarily focuses on symptomatic relief using traditional medicines such as proton pump inhibitors, like omeprazole and lansoprazole. If Helicobacter pylori infection is present, antibacterial treatment is generally needed, using either triple or quadruple antibiotic therapy; triple therapy consists of a proton pump inhibitor plus two antibiotics, and adding bismuth forms quadruple therapy. One treatment cycle lasts two weeks, and after completing medication, Helicobacter pylori can be rechecked in one month. Additionally, it's important to maintain good dietary and living habits. If recurrent duodenal bulb ulcers cause bleeding at night, surgical treatment can typically be considered.

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Written by Jiang Guo Ming

Gastroenterology

43sec

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Where does a duodenal ulcer hurt?

Firstly, the common sites for duodenal ulcers are the anterior and posterior walls posterior to the bulb, as well as the area behind the duodenal bulb itself. The pain symptoms typically show a pattern. For example, the pain occurs in recurrent, cyclical episodes related to eating, manifesting as sporadic abdominal pain about 2cm above the right side of the belly button, more pronounced on an empty stomach, and alleviating after meals. Sometimes, there is also pain during the night. If the ulcer is located behind the duodenal bulb, it often causes back pain. The main cause is usually an infection with Helicobacter pylori, and eradication therapy can generally cure the condition.

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Written by Si Li Li

Gastroenterology

54sec

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Differentiation between Duodenal Ulcer and Gastric Ulcer

Duodenal ulcers and gastric ulcers primarily differ in their locations: duodenal ulcers occur in the mucosa of the duodenum, whereas gastric ulcers are found in the gastric mucosa. Secondly, the characteristics of upper abdominal pain differ between the two. Pain from duodenal ulcers typically worsens when hungry and lessens after eating, whereas with gastric ulcers, pain intensifies after eating and decreases when hungry. Thirdly, the prognosis differs; gastric ulcers have a certain potential for malignant transformation, and some large ulcers may already be gastric cancer, while duodenal ulcers rarely develop into malignant tumors. It is advisable to undergo active treatment after a clear diagnosis.