Many patients who have suffered from epididymitis will have a hard, smooth-surfaced, slightly tender, or asymptomatic nodule left on the epididymis after the swelling subsides and pain is controlled. This type of nodule is also referred to as a negative nodule. These nodules are difficult to completely eliminate with antibiotics, or may not be eliminated at all.

If the patient does not have significant discomfort, no special treatment is necessary. If the presence of the nodule leads to recurrent inflammation or significant pain, affecting the patient's normal work and life, it may be considered to apply local heat or gently massage to promote the reduction of the nodule. If these treatments do not effectively improve the condition, it is recommended to surgically remove the nodule from the epididymis.