Understanding the gender differences in the prevalence of various diseases has important practical significance for the occurrence, development, and prevention of diseases. Research in this area has gradually gained attention from health prevention workers and provides a scientific basis for health prevention efforts.

Various clinical studies indicate that the prevalence of gallstones is significantly higher in women than in men, with an incidence ratio of about 3:1 in the affected population. With economic development, people's lifestyles and dietary structures have undergone tremendous changes, leading to an increasing trend in the incidence of gallstones. In China, approximately 8%-11% of patients suffer from gallstones, predominantly obese women around forty years old, often referred to by the three Fs: fat, forty, female.