If gallstones are not treated promptly, the probability of developing gallbladder cancer is higher than in healthy individuals. Long-term untreated gallstones can irritate the gallbladder, leading to decreased gallbladder function and causing cancerous changes. Chronic thickening of the gallbladder wall can occur from prolonged episodes of gallstones, worsening inflammation, which can lead to more severe inflammation of the gallbladder mucosa and result in cancerous changes. In fact, gallstones are an important factor in the development of gallbladder cancer. However, not all patients with gallbladder cancer have gallstones, but clinically, about 70% of patients with gallbladder cancer have concurrent gallstones. Therefore, even if patients with gallstones do not exhibit symptoms, they should be particularly cautious and undergo regular physical examinations annually to detect problems early and treat them promptly.