The enlargement of the inguinal lymph nodes is not significantly related to varicocele. The enlargement of lymph nodes in the inguinal area is mostly due to bacterial or viral infections in the lower limbs or throughout the body, lymphomas, as well as malignancies in the abdominal or pelvic area. Varicocele, meanwhile, is mostly caused by high pressure in the spermatic veins or some physiological factors that lead to the twisting and dilation of these veins. The two conditions are not directly related, and their incidence rates also differ. Additionally, the enlarged lymph nodes can generally be differentiated from varicocele through color ultrasound, and the treatment methods are different. Most varicoceles are resolved surgically; whereas enlarged inguinal lymph nodes can be treated conservatively with oral medication.