Clinical manifestations of hyperkalemia

Written by Zhao Xin Lan
Endocrinology
Updated on October 29, 2024
00:00
00:00

The clinical manifestations of hyperkalemia are not specific. Early symptoms often include numbness in the limbs, sensory abnormalities, extreme fatigue, and muscle pain. In severe cases, there can be difficulties in swallowing, speaking, and breathing, paralysis of the limbs, and tendon reflexes may disappear. The central nervous system may show signs of restlessness, fainting, and confusion. Some may experience a slow heart rate, ventricular fibrillation, and in the most severe cases, it can lead to cardiac arrest. Other symptoms may include nausea, vomiting, diarrhea, and other gastrointestinal symptoms.

Other Voices

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
49sec home-news-image

What are the symptoms of hyperkalemia?

The effects of hyperkalemia on the body mainly include the following aspects: First, the impact on muscle tissue: mild hyperkalemia can cause slight tremors in muscles. If the potassium levels continue to rise, this can lead to decreased neuromuscular excitability, resulting in limbs becoming weak and flaccid, and even leading to delayed paralysis. Second, the impact on the cardiac system: it can cause a decrease in myocardial excitability, conductibility, and automaticity. The electrocardiogram shows a depressed P wave, widened QRS complex, shortened QT interval, and peaked T waves. Third, hyperkalemia affects acid-base balance and can lead to metabolic acidosis during hyperkalemia.

doctor image
home-news-image
Written by Chen Li Ping
Endocrinology
57sec home-news-image

Can hyperkalemia be cured?

The main focus is on the cause of hyperkalemia. If hyperkalemia is due to consuming foods rich in potassium, administration of potassium-containing solutions, transfusion of stored blood, use of potassium-sparing diuretics like spironolactone, or prolonged venipuncture causing severe shaking of the blood sample during transport, addressing these causes can prevent the occurrence of hyperkalemia. If hyperkalemia is caused by certain diseases, such as renal failure or adrenal insufficiency, active treatment of the underlying disease is required. If the renal failure is acute, recovery of kidney function might prevent the recurrence of hyperkalemia. However, if there is chronic renal insufficiency, there tends to be a higher recurrence rate of hyperkalemia. Therefore, whether hyperkalemia can be cured largely depends on identifying the underlying cause.

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
42sec home-news-image

The effects of hyperkalemia on the body

Hyperkalemia affects the body mainly in three aspects. Firstly, hyperkalemia impacts muscle tissues, clinically manifesting as symptoms such as muscle tremors. Secondly, the effect of hyperkalemia on the heart primarily manifests as decreased excitability, conductivity, and automaticity of the myocardium. It affects electrocardiograms, characterized by a depressed P wave, widened QS wave, reduced R wave, and elevated T wave. Thirdly, hyperkalemia affects acid-base balance; during hyperkalemia, potassium efflux from cells can lead to metabolic acidosis, resulting in alkaline urine.

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
46sec home-news-image

What are the symptoms of hyperkalemia?

Mild hyperkalemia can affect muscle tissues, causing mild muscle tremors, while severe hyperkalemia may reduce the excitability of neuromuscular functions, leading to weakness and even flaccid paralysis in the limbs. Hyperkalemia can also impact the heart, mainly resulting in decreased myocardial excitability, decreased myocardial conductivity, and decreased myocardial automaticity. The effects on the electrocardiogram (ECG) primarily manifest as low and widened P waves, widened QS complexes, decreased R waves, and elevated T waves. Regarding myocardial contractility, hyperkalemia mainly causes a decrease in contractility and can lead to metabolic acidosis.

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
34sec home-news-image

Does hyperkalemia cause a fast or slow heart rate?

Hyperkalemia often causes a slowed heart rate and is associated with various arrhythmias. When serum potassium is between 6.6 to 8.0 mmol/L, tented T-waves may be observed. When serum potassium levels rise rapidly, it can lead to ventricular tachycardia or even ventricular fibrillation. On the other hand, a slow increase in serum potassium can cause conduction blocks, and in severe cases, may lead to cardiac arrest. These are the heart rate changes caused by hyperkalemia, which typically result in a slower heart rate.