What are the symptoms of hyperkalemia?

Written by Wei Shi Liang
Intensive Care Unit
Updated on September 02, 2024
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The effects of hyperkalemia on the body mainly include the following aspects:

First, the impact on muscle tissue: mild hyperkalemia can cause slight tremors in muscles. If the potassium levels continue to rise, this can lead to decreased neuromuscular excitability, resulting in limbs becoming weak and flaccid, and even leading to delayed paralysis.

Second, the impact on the cardiac system: it can cause a decrease in myocardial excitability, conductibility, and automaticity. The electrocardiogram shows a depressed P wave, widened QRS complex, shortened QT interval, and peaked T waves.

Third, hyperkalemia affects acid-base balance and can lead to metabolic acidosis during hyperkalemia.

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Written by Wei Shi Liang
Intensive Care Unit
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Common symptoms of hypokalemia and hyperkalemia

The common symptoms of hyperkalemia and hypokalemia, mainly seen in severe cases of high or low potassium, manifest as neurological and muscular symptoms as well as circulatory system symptoms, which are fairly similar in both conditions. If the blood potassium is particularly low, less than 2.0 mmol per liter, it can lead to reduced or absent reflexes. In severe cases, this may progress to paralysis of the respiratory muscles, causing respiratory pump failure. For hyperkalemia, particularly severe cases may also present with swallowing difficulties and respiratory distress. These central nervous system issues can lead to confusion and fainting. Another similar issue is the impact on the circulatory system; severe hypokalemia can cause ventricular tachycardia and even ventricular fibrillation, leading to death. In hyperkalemia, the impact on the cardiovascular system primarily causes malignant tachycardia and can also result in ventricular fibrillation. The main cause of sudden death in hyperkalemia is ventricular fibrillation and cardiac arrest, demonstrating that severe hyperkalemia and hypokalemia similarly cause significant arrhythmic conditions in the heart.

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How to treat vomiting caused by hyperkalemia?

For patients with hyperkalemia, early symptoms include numbness in the limbs, weakness, muscle soreness, and paralysis. As the condition progresses, it can suppress myocardial function, reducing the tension of the myocardium and leading to slow heartbeats, and even cause arrhythmias and cardiac arrest. Increased release of acetylcholine can also cause nausea, vomiting, abdominal pain, and other symptoms. Patients with this condition generally also exhibit symptoms of hyperlipidemia and metabolic acidosis. For mild cases of hyperkalemia, temporary treatment may not be necessary, and symptomatic treatment such as stopping vomiting and drinking water may be sufficient. However, in acute cases, it is recommended that the patient immediately undergo dialysis or receive diuretic injections to rapidly eliminate potassium ions from the body, and to stop consuming foods and medications that contain potassium.

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Written by Wei Shi Liang
Intensive Care Unit
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Clinical manifestations of hyperkalemia

The clinical manifestations of hyperkalemia mainly affect the cardiovascular system, often presenting with slowed heart rate and various arrhythmias. When the blood potassium level is between 6.6 and 8.0 mmol/L, a tent-shaped T-wave can be observed. Rapid increases in blood potassium can lead to ventricular tachycardia, and even ventricular fibrillation. A gradual increase in blood potassium can cause conduction blocks, and in severe cases, cardiac arrest. Sudden death in severe hyperkalemia is mainly due to ventricular fibrillation and cardiac arrest. The second aspect is symptoms related to the neuromuscular system. As the concentration of potassium ions in the extracellular fluid increases, the resting membrane potential drops, leading to muscle weakness and even paralysis, typically more pronounced in the lower limbs and extending upward along the trunk. In severe cases, some patients may experience difficulty in swallowing and breathing difficulties. Symptoms involving the central nervous system mainly include restlessness, confusion, and fainting.

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Written by Wei Shi Liang
Intensive Care Unit
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Causes of Hyperkalemia

Common causes of hyperkalemia in clinical settings include: First, it is related to excessive intake. Generally, a high-potassium diet under normal kidney function does not cause hyperkalemia. It only occurs when there is excessive or rapid intravenous potassium supplementation, or when kidney function is impaired. Second, hyperkalemia caused by reduced excretion. Common reasons include renal failure, lack of adrenocortical hormones, and primary renal tubular potassium secretion disorders, all of which can cause hyperkalemia. Third, a large transfer of potassium ions from inside the cells to the outside can also cause hyperkalemia.

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Written by Wei Shi Liang
Intensive Care Unit
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How to rescue hyperkalemia

Hyperkalemia must be dealt with immediately once it occurs. The usual treatments in clinical settings include promoting potassium excretion using furosemide or other loop diuretics to maximize renal potassium excretion, or using oral or rectal potassium-eliminating agents. For life-threatening hyperkalemia with serum potassium levels greater than 6.5 mmol/L, hemodialysis is necessary. Another approach is to facilitate the shift of potassium into cells, which is done through the administration of insulin with glucose, or sodium bicarbonate along with calcium gluconate that helps protect the myocardium, thus providing treatment and protective measures for hyperkalemia.