How to treat advanced gastric cancer?

Written by Liu Liang
Oncology
Updated on September 03, 2024
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The treatment for advanced gastric cancer is primarily chemotherapy, especially for patients with peritoneal or retroperitoneal lymph node metastasis, or distant organ metastasis such as to the liver or lungs. The treatment primarily involves chemotherapy, specifically choosing either multi-drug intravenous combination chemotherapy or oral monotherapy, such as oral chemotherapy with tegafur capsules, or broad-spectrum targeted therapies like apatinib that inhibit angiogenesis. The choice of treatment depends on a comprehensive consideration of the patient's overall condition. If the patient's general condition is particularly poor and the chemotherapy risk is assessed to be high, then the approach for such advanced-stage patients is primarily the best symptomatic supportive treatment to alleviate suffering as much as possible. Therefore, the treatment plan must be determined based on a comprehensive consideration of the specific situation.

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Written by Liu Liang
Oncology
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Can stomach cancer be cured?

Whether gastric cancer can be cured depends on the stage of the cancer, as well as the patient's own physical condition. For example, early-stage gastric cancer patients, who are diagnosed as early-stage through examinations such as endoscopic ultrasonography and enhanced CT of the chest and abdomen, and assessed by surgeons as suitable for curative surgery, are primarily treated with curative surgery. The prognosis for these early-stage gastric cancer patients is generally good, with a relatively high five-year survival rate. Post-operation, based on the pathological findings, it is decided whether postoperative adjuvant radiotherapy and chemotherapy are necessary. There is hope for curing patients in these early stages through these treatment methods. However, if a patient is found to have advanced-stage gastric cancer, for example with metastases to distant organs like the liver and lungs, the cancer is not completely curable. The purpose of treatment in such cases is to alleviate the patient's pain and extend their survival, but it can’t achieve a curative effect.

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Written by Liu Liang
Oncology
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early symptoms of gastric cancer

The early symptoms of gastric cancer are similar to those of some gastrointestinal diseases such as gastritis, gastric ulcers, or duodenal ulcers. They don't have very specific clinical manifestations. Common symptoms include nausea, vomiting, discomfort or pain in the upper abdomen, and acid reflux-like symptoms, which are early symptoms in patients with gastric cancer. Therefore, when such symptoms appear, it is essential to seek medical attention promptly and undergo a thorough gastroscopy.

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Written by Liu Liang
Oncology
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Does early-stage stomach cancer hurt?

Symptoms of early-stage gastric cancer are generally not very obvious. Some patients may experience subtle symptoms resembling those of gastritis or gastrointestinal ulcers, including non-specific gastrointestinal symptoms such as discomfort and bloating in the upper abdomen, acid reflux, nausea, vomiting, and decreased appetite. In terms of pain, early-stage gastric cancer patients might only experience a sensation of bloating or mild tenderness in the upper abdomen. Severe pain is usually associated with late-stage gastric cancer, occurring when there is extensive abdominal metastasis or tumor progression, and the tumor is large enough to cause significant pain, requiring analgesics for treatment.

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Written by Liu Liang
Oncology
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How is stomach cancer treated?

The treatment for gastric cancer now includes surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, among others. The specific treatment plan is formulated based on various factors such as the staging of the cancer, the patient's overall condition, and the presence of any underlying diseases, which are all taken into consideration before deciding on a treatment plan. For patients in the early stages who are generally in good condition, surgical resection can be evaluated and is primarily curative. Post-operative treatment decisions, such as whether to pursue adjuvant radiotherapy or chemotherapy, depend on the pathology results and the presence of high-risk factors for recurrence. For patients in advanced stages who are found to have distant metastases upon diagnosis, treatment is primarily chemotherapy. Additionally, there are broad-spectrum targeted therapies against angiogenesis, such as apatinib, which are suitable for patients with advanced gastric cancer or those who do not respond well to chemotherapy, serving as a secondary or tertiary line of treatment. These are some of the treatment methods for gastric cancer. It is crucial that the use of any medication is conducted under the guidance of a doctor.

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Written by Liu Liang
Oncology
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Can stomach cancer be cured? Can stomach cancer be cured?

Early-stage gastric cancer patients can undergo curative surgery, and then decide whether postoperative adjuvant radiochemotherapy is needed based on the specific pathological type and the presence of high-risk recurrence factors. Through these treatments, a cure can be achieved. Generally, if there is no recurrence or metastasis within five years, it is considered cured. For example, patients in stage IA, even without adjuvant chemotherapy, have a relatively high five-year survival rate, generally above 90% after curative surgery. However, if it is found to be advanced-stage, such as initial detection showing distant metastases to the liver, lungs, etc., these patients are primarily treated with systemic chemotherapy or symptomatic palliative care. In such cases, a cure is not achievable. Therefore, whether a cure is possible depends on the stage of gastric cancer and factors such as the patient's basic physical condition.