Peripheral vascular signs refer to a medical sign characterized by enhanced pulsation of the peripheral arteries and capillaries due to increased pulse pressure. Patients with a patent ductus arteriosus can experience increased pulse pressure, leading to rapid rises and falls in pressure within the peripheral vessels, thereby causing a series of peripheral vascular signs. When a patent ductus arteriosus is combined with peripheral vascular signs, indicating a substantial shunt, it is advisable for such individuals to undergo surgery as soon as possible. Delaying surgery may lead to a right-to-left shunt, resulting in Eisenmenger's syndrome, and the loss of the opportunity for surgical intervention.