Small cell lung cancer and non-small cell lung cancer differences

Written by Xia Bao Jun
Pulmonology
Updated on January 27, 2025
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Small cell lung cancer and non-small cell lung cancer are both types of primary bronchogenic carcinoma, differing only in their cellular morphology. They also differ in clinical symptoms and characteristics of metastasis. Small cell lung cancer is more prone to metastasis clinically, including strenuous and distant spread, such as to the brain and liver. The medications used for each are also different; small cell lung cancer typically involves chemotherapy drugs like etoposide and cisplatin, whereas non-small cell lung cancer commonly uses drugs like paclitaxel and platinum-based drugs.

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Written by Liu Liang
Oncology
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Is lung cancer contagious?

The occurrence of lung cancer is associated with smoking, air pollution, and working in environments such as coal mining. However, lung cancer is not contagious. Therefore, in clinical settings, family members of patients often ask doctors whether lung cancer can be transmitted through the respiratory tract. It can be assured that lung cancer is not contagious; only communicable diseases like tuberculosis can be spread this way.

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Written by Gong Chun
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How to check for lung cancer?

How to check for lung cancer, firstly, for lung cancer screening, particularly in people over forty years old, especially smokers, it is recommended to regularly undergo low-dose spiral CT scans of the chest. Secondly, if a tumor is detected, it is suggested to proceed with enhanced CT scans, sputum cytology tests, or PET-CT. If it is confirmed that there is a tumor in the lungs, then a biopsy is needed. The biopsy can be performed under bronchoscopy, or transthoracic lung puncture and biopsy of living tissue can also be done, as well as biopsy of metastatic lesions or cytological examination of pleural effusion to diagnose whether it is lung cancer, the type of lung cancer, and certain immunohistochemical situations.

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Written by Wang Chun Mei
Pulmonology
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How to treat dry cough caused by lung cancer?

Dry cough is a very common symptom in clinical practice, caused by many factors which are also very complex. Some patients might clearly have lung cancer. Due to the presence of lung cancer lesions, patients can experience irritating dry cough as well as symptoms like hemoptysis, chest pain, and chest tightness. It is possible that some patients do not exhibit symptoms of dry cough, perhaps due to other causes. Therefore, for dry cough, we need to identify if it is caused by lung cancer, as it often requires surgical treatment to control the symptoms. Some patients with minor lung cancer who experience dry cough might be able to control it with appropriate medications. However, to effectively control symptoms of dry cough caused by lung cancer, surgical removal is generally necessary and is the ultimate treatment plan.

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Written by Gong Chun
Oncology
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What are the symptoms of lung cancer?

The most common symptoms of lung cancer include coughing, particularly irritating coughs, and symptoms of coughing up blood. The blood in the sputum may appear as spots, streaks, or intermittent small amounts. Other symptoms include difficulty breathing and chest pain, as well as potential tightness in the chest, shortness of breath, and fever. Secondly, if lung cancer grows within the thoracic cavity and spreads, invading nearby tissues and organs, it can produce secondary symptoms. For example, paralysis of the phrenic nerve on the same side may lead to difficulty breathing and belching. Compression of the recurrent laryngeal nerve may cause hoarseness; compression of the superior vena cava can lead to distended veins in the face, neck, and upper limbs; subcutaneous edema; and if the pleura is invaded, it can cause pleural effusion, among other symptoms. If lung cancer metastasizes through the bloodstream, it may spread to the brain and potentially lead to symptoms such as headaches, nausea, and vomiting. Metastasis to different regions of the brain might cause various symptoms, including seizures, mental confusion, and vision impairment. In a minority of cases, lung cancer may produce endocrine substances, possibly leading to symptoms like severe muscle weakness, bone and joint pain, and other such symptoms.

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Written by An Yong Peng
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Can early-stage lung cancer cause shoulder pain?

In the early stages of lung cancer, it generally does not cause shoulder pain. Early-stage lung cancer often does not involve critical structures and typically does not produce noticeable clinical symptoms. However, a small number of central lung cancers may cause symptoms related to coughing. Moreover, shoulder pain can occur in cases of lung cancer, often seen in superior sulcus tumors. A superior sulcus tumor, also known as a Pancoast tumor, is a tumor located at the top of the lung. As the tumor grows, it may compress the brachial plexus nerves, leading to symptoms such as shoulder pain and throat pain. It can also cause symptoms like enophthalmos (sunken eyeball) and pupil constriction. Therefore, when encountering these signs clinically, it is necessary to consider the possibility of a superior sulcus tumor and conduct examinations like a chest CT scan for evaluation.