Rheumatoid arthritis during the acute flare-up phase makes heat application useless; it might even exacerbate the symptoms of joint pain. Normally in daily life, applying heat to the affected joints can assist in treatment. However, during the acute flare-up phase of rheumatoid arthritis, the main symptoms are migratory pain in the major joints of the limbs. Cold application may help alleviate the pain, but heat should definitely not be applied during the acute phase. The development of rheumatoid arthritis is somewhat related to streptococcal infections. Therefore, penicillin antibiotics are generally used for anti-infection treatment. During the acute phase, it is common to also use non-steroidal anti-inflammatory drugs, such as etoricoxib or meloxicam, to relieve symptoms.