Difference between arthritis and rheumatoid arthritis

Written by Guan Yu Hua
Orthopedic Surgery
Updated on December 05, 2024
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Arthritis is typically osteoarthritis, a chronic inflammation characterized primarily by degenerative changes in joint cartilage, followed by bone proliferation, making it a chronic disease. Early pathological changes include alterations in joint cartilage, such as subchondral bone extrusion, followed by changes in the muscles surrounding the periosteum and joint capsule. Early radiographic examinations can provide a definitive diagnosis. Its symptoms primarily manifest as pain. For rheumatoid arthritis, it generally presents as morning stiffness and joint swelling and pain more severe than in the surrounding area, which can essentially confirm a diagnosis. It usually affects large joints such as the knee, shoulder, or wrist joints, typically presenting as migratory pain. A definitive diagnosis can usually be made by testing for rheumatoid factor, with an anti-O level exceeding 500 units. Additionally, there may be a slight increase in white blood cells, accelerated erythrocyte sedimentation rate, and elevated C-reactive protein. Examination of the synovial fluid shows increased white blood cells and neutrophils. In such cases, using anti-rheumatic drugs might suffice, but it’s also crucial to ensure rest and local heat application. These two types of arthritis fundamentally differ.

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Written by Yang Ya Meng
Rheumatology
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Rheumatoid Arthritis Diagnostic Criteria

The diagnostic criteria for rheumatoid arthritis include, first, the presence of swelling and pain in multiple joints, especially characterized and significant in the smaller joints. Second, serological tests show elevated levels of antibodies, commonly rheumatoid factor and anti-CCP antibodies. If both are elevated, it is most meaningful. Third, the duration of joint swelling and pain should be more than six weeks. Fourth, we must also check some inflammatory markers for joints, such as elevated erythrocyte sedimentation rate and C-reactive protein. If these markers are elevated, and the patient has swelling and pain in multiple joints, then we can consider a diagnosis of rheumatoid arthritis.

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Written by Yang Ya Meng
Rheumatology
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What medicine should be taken for rheumatoid arthritis?

Medications for rheumatoid arthritis firstly include some anti-inflammatory and analgesic drugs, commonly used are non-steroidal pain relievers such as Diclofenac Sodium Sustained Release Tablets and the like. The second, and most important, are what we call slow-acting drugs, which are often immunosuppressants, commonly used ones include Methotrexate, Leflunomide Tablets and the like. If the patient does not respond well to conventional oral medications, we can also use biologic treatments. Before using biologics, we need to strictly rule out hepatitis, tuberculosis, tumors, and some common infections. Commonly used biologics include tumor necrosis factor antagonists and similar drugs. (The use of medications should be conducted under the guidance of a professional doctor.)

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Written by Lv Yao
Orthopedics
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The difference between osteoarthritis and rheumatoid arthritis.

Osteoarthritis refers to the damage of joint cartilage due to degeneration in old age, which can cause symptoms such as joint pain, limited mobility, and deformity. Rheumatoid arthritis, on the other hand, involves the destruction of joint cartilage solely due to rheumatic diseases, particularly accompanied by abnormal proliferation of the synovium, causing pain and local heating, and resulting in limited joint mobility. Rheumatic diseases feature migrating joint pain, which worsens when exposed to cold. Additionally, diagnostic indicators such as positive rheumatoid factor will show increased levels, thus making it relatively easy to distinguish between osteoarthritis and rheumatoid arthritis.

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Written by Yang Ya Meng
Rheumatology
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How is rheumatoid arthritis treated?

The treatment methods for rheumatoid arthritis mainly fall into three categories: The first category is anti-inflammatory analgesics, which include non-steroidal analgesic drugs such as slow-release diclofenac sodium. For patients with especially high inflammatory indicators, low-dose corticosteroids may also be considered. The second category of drugs includes slow-acting drugs commonly used in the treatment of rheumatoid arthritis, such as methotrexate and leflunomide, which are immunosuppressants. If the patient does not respond well to non-steroidal analgesic drugs or immunosuppressants, biological agents can be considered as a treatment option. Common biological agents include tumor necrosis factor antagonists. (Specific medications should be taken under the guidance of a physician.)

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Written by Li Jing
Rheumatology
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Treatment of Acute Flare-ups of Rheumatoid Arthritis

During the acute phase of rheumatoid arthritis, typical treatment includes absolute bed rest and avoiding intense physical activities, followed by a diet rich in fresh fruits and vegetables containing vitamins. Medication-wise, sodium diclofenac or meloxicam are used, which are non-steroidal drugs that relieve joint pain. If these drugs are not effective, steroids such as methylprednisolone are administered, initially at doses of 20 mg or 40 mg, until the pain eases, then gradually reducing the steroid dosage. During steroid treatment, it's also important to prevent side effects, namely, by supplementing with calcium and incorporating drugs that protect the stomach lining. (The above medications should be used under medical supervision.)