Can early lupus nephritis be cured?

Written by Liu Li Ning

Rheumatology

Updated on February 17, 2025

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Early stage lupus nephritis does not have a cure. Some patients can achieve clinical remission by strictly adhering to a certain medication. Systemic lupus erythematosus can involve multiple systems and organs throughout the body. The kidneys are one of the most commonly affected target organs. Research shows that if systemic lupus erythematosus is diagnosed, performing a kidney biopsy will reveal lupus nephritis in almost 100% of the cases. The main treatment for lupus nephritis involves long-term maintenance with corticosteroids and immunosuppressants. Commonly used immunosuppressants include cyclophosphamide, mycophenolate mofetil, cyclosporine, azathioprine, and tacrolimus.

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Patients with lupus often experience recurrent, stubborn skin lesions on their hands or face, and some may even develop ulceration, atrophy, or scarring on top of the existing erythema. Most lupus patients exhibit erythema, centered around the bridge of the nose and appearing on the cheeks. The lesions are disc-like on both sides with generally clear boundaries, either flat or slightly raised, and are categorized as exudative inflammation. Depending on the severity of the inflammation, the erythema can range from light red, bright red to purple-red. In severe cases, localized edema resembling erysipelas may occur, and scaling and hyperpigmentation may appear as the inflammation subsides. Facial rashes generally resolve, and most rashes do not leave marks after resolution. If hyperpigmentation remains after the erythema has resolved, it suggests a good prognosis. However, erythema in other areas, such as acral erythema and reticular cyanosis, may last for varying durations depending on the patient's individual condition.

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Does lupus erythematosus transmit through living and eating together?

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