Early symptoms of lymphoma

Written by Peng Li Bo
Oncology
Updated on November 03, 2024
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The early symptoms of lymphoma involve the painless enlargement of both superficial and deep lymph nodes, most commonly located in areas such as the neck, armpits, and groin. Of course, lymphoma also presents with systemic symptoms, such as fever, night sweats, weight loss, and skin itching. Since lymphoma commonly occurs in the neck, armpits, and groin, if it develops in other areas, such as the lungs or elsewhere, it may cause respiratory symptoms, including coughing, expectoration, and shortness of breath.

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Written by Peng Li Bo
Oncology
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What is lymphoma Ki-67?

Lymphoma Ki67, also known as the proliferation index, is one of the indicators in immunohistochemistry performed after the pathological diagnosis of lymphoma. If this proliferation index is higher, it indicates that the activity of the tumor is stronger, and its proliferation is more active, thus the tumor should be given sufficient attention. Of course, active treatment should be pursued. Therefore, Ki67 reflects the activity of a tumor; if the index is very high, greater than 90%, it sometimes implies that the tumor can grow very rapidly, or not only grows significantly but might also spread to many places.

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Written by Liu Liang
Oncology
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The pattern of fever in lymphoma

Fever symptoms are quite common in patients with lymphoma, which we refer to as B symptoms. The pattern of their fevers is primarily low-grade, occurring more frequently in the afternoon or evening. Unlike ordinary bacterial infections, fevers in these patients do not respond well to anti-inflammatory drugs, but they do respond better to steroid treatment for reducing fever. However, if the lymphoma is not under control, their fever will repeatedly recur. Corresponding cooling treatments can reduce the temperature, but the fever will reoccur repeatedly. Only when the lymphoma and tumor are under control will the fever symptoms start to improve.

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Written by Liu Liang
Oncology
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Is lymphoma serious?

The severity of lymphoma relates to its specific pathological type and the stage of discovery among other factors. For instance, some highly aggressive lymphomas grow very rapidly, leading to swift disease progression, resulting in a poorer prognosis and more severe conditions. On the other hand, indolent lymphomas progress slowly, with lymph node growth being particularly sluggish, and the disease course can extend to even decades. Thus, conditions of such indolent lymphomas are relatively milder. The stage of lymphoma at the time of discovery also plays a role; early-stage lymphoma, such as stage I or II, is comparatively less severe. In contrast, patients with later stages, such as stage III or IV, experience more severe conditions. Therefore, the type of pathology and the stage at discovery are all significant factors.

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Written by Liu Liang
Oncology
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Causes of Malignant Lymphoma

The causes of malignant lymphoma are the result of multiple factors. First, it is associated with infections by bacteria or viruses, such as the well-documented chronic infection with Helicobacter pylori, which is closely related to the occurrence of lymphoma associated with the gastric mucosa. Second, immunodeficiency conditions, like in AIDS patients or those who have been taking immunosuppressive drugs for a long period, have a higher likelihood of developing malignant lymphoma compared to the general population. Third, chemical or physical factors, such as environmental carcinogens and electromagnetic radiation, can also lead to malignant lymphoma. Other factors, such as long-term use of certain drugs like phenytoin or pseudoephedrine, and a genetic predisposition, can also be causes of malignant lymphoma.

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Written by Wu Xia
Oncology
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How long can lymphoma last?

In clinical practice, lymphomas are classified into Hodgkin's lymphoma and non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma is a relatively common type of tumor in China and has the highest incidence among lymphomas. However, it is further divided into dozens of subtypes, each with distinct clinical symptoms. Aggressive lymphomas can be cured, while indolent lymphomas can be managed with the tumor remaining. Thus, the question of how long one can live with lymphoma cannot be generalized; it depends on the type and stage of the disease, and many can be cured completely.