People with ALS often experience soreness and pain in their legs when lying down. In patients with ALS, certain neurons in the brain and spinal cord gradually degenerate and die, leading to muscle atrophy, nerve damage, muscle weakness, and stiffness, as if they are frozen. This muscle damage can lead to symptoms such as sore legs, general weakness, and fatigue. Over time, it may also cause difficulties in walking, speaking, eating, choking while drinking water, swallowing, and breathing. This can lead to systemic damage, complications like breathing difficulties, respiratory failure, and ultimately threaten life. The symptoms of leg pain and soreness in people with ALS, when lying down, can be alleviated through acupuncture, physical therapy, massage, and heat application.