How is prostate cancer formed?

Written by Liu Liang
Oncology
Updated on November 20, 2024
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The causes of prostate cancer are not yet very clear. According to relevant data analysis, the occurrence of prostate cancer may be related to prostate gonorrhea, infections with viruses or chlamydia, as well as the intensity of sexual activity and the impact of hormones. On the other hand, a high-fat diet and some occupational factors are also somewhat related to the disease. Therefore, the formation of prostate cancer is the result of multifactorial influences including environmental and genetic factors, personal lifestyle habits, and dietary habits, all of which are significantly interconnected.

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Pathological classification of prostate cancer

The classification of precancerous lesions of prostate cancer is divided into two categories: intraductal carcinoma of the prostate and atypical adenomatous hyperplasia. Among these, the relationship between intraductal carcinoma of the prostate and prostate cancer is the closest. Intraductal carcinoma of the prostate is currently recognized as a precancerous lesion of prostate cancer, while atypical adenomatous hyperplasia has not been proven to be a precancerous lesion of prostate cancer according to current evidence. However, the biological behavior of this atypical adenomatous hyperplasia is not very clear yet, so it should be closely monitored. The histological classification of prostate cancer mainly includes the majority of acinar adenocarcinoma and a small amount of ductal adenocarcinoma, with acinar adenocarcinoma being a highly invasive malignant tumor.

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Typical symptoms of prostate cancer

Early-stage prostate patients often do not exhibit significant clinical symptoms. However, when the prostate cancer tumor invades the surrounding tissues and structures, it can cause corresponding clinical manifestations such as urinary tract irritation and urinary obstruction. Symptoms include difficulty urinating or frequent urination, painful urination, and even urinary incontinence, perineal pain, and sciatica. Bone metastasis is a common site of metastasis in prostate cancer patients, causing pain in the affected area and even pathological fractures.

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Is chemotherapy for prostate cancer painful?

For patients with advanced prostate cancer, endocrine therapy is primarily used. Chemotherapy is generally chosen when endocrine therapy is resistant and ineffective. The side effects of chemotherapy are similar to those of other chemotherapy treatments. The first is the gastrointestinal side effects, such as nausea, vomiting, decreased appetite, or bloating and abdominal pain. The second is bone marrow suppression, which leads to a decrease in white blood cells and platelets. The side effects of chemotherapy vary with each patient's constitution and other factors. In most cases, with the support of medications for stomach protection, anti-nausea, and increasing white blood cells, the majority of patients can generally tolerate the treatment.

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What are the symptoms of prostate cancer?

Early-stage prostate cancer generally has no symptoms, but if the patient also has prostate enlargement, or in cases of mid to late-stage prostate cancer where the tumor invades the urethra or bladder, various degrees of urinary obstruction or irritative urinary symptoms may occur. This is characterized by frequent urination and urgency. If there are local infiltrative symptoms, perineal pain and sciatica might occur. If the vas deferens is compressed, it can cause back pain and pain in the testicles on the affected side. Invasion of the rectum can cause difficulty in defecation or obstruction of the colon, and if the membranous part of the urethra is involved, urinary incontinence may occur. The most common site of metastasis for prostate cancer is the bones. If it spreads to the bones, it can cause bone pain, pathological fractures, anemia, and spinal cord compression leading to paralysis of the lower limbs.

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Oncology
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Best treatment methods for prostate cancer

Treatment methods for prostate cancer include surgery, radiotherapy, chemotherapy, and endocrine therapy, among others. The choice of specific treatment methods is comprehensively considered based on the stage of the disease and the patient's physical condition. Early-stage prostate cancer patients can choose prostatectomy or radical radiotherapy. For patients with locally advanced T3 or T4 stage prostate cancer, since the efficacy of prostatectomy alone is relatively poor, radiotherapy combined with endocrine therapy can be chosen. For patients with metastatic prostate cancer, those who are found to have bone metastasis or distant metastasis from the onset, endocrine therapy is primarily used. If endocrine therapy is ineffective or fails, chemotherapy can also be adopted for these late-stage metastatic prostate cancer patients. If the bone metastasis causes pain, local radiotherapy can also be used to alleviate the pain symptoms.