Endocrine therapy after radical prostatectomy for prostate cancer

Written by Zhou Zi Hua
Oncology
Updated on September 16, 2024
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Endocrine therapy after radical prostatectomy for prostate cancer is equivalent to adjuvant endocrine therapy for prostate cancer. Its purpose is to treat residual lesions, positive residual lymph nodes, and microscopic metastatic foci, thereby improving long-term survival rates. Currently, the indications for adjuvant endocrine therapy are based on postoperative pathology-positive results, positive lymph nodes post-surgery, and postoperative pathology confirmation of stage T3 or T4, but with high-risk factors. According to major guidelines, the duration of adjuvant endocrine therapy should be at least eighteen months.

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The difference between benign prostatic hyperplasia and prostate cancer.

Prostatic hyperplasia and prostate cancer are sometimes very difficult to distinguish clinically, as both diseases occur in elderly men, can cause lower urinary tract symptoms, and lead to elevated PSA levels. However, prostatic hyperplasia generally has a longer medical history, whereas prostate cancer has a shorter history and progresses more quickly. During a digital rectal exam for prostatic hyperplasia, the gland appears enlarged and the surface is smooth. In contrast, during a prostate exam, the gland may show irregular enlargement, a rough surface, and the tumor feels firm. When these two are difficult to distinguish, considering a prostate biopsy may be advisable.

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Prostate cancer radiotherapy is conducted in what way?

Indications for radiation therapy for prostate cancer include clinical stages T1 to T4, M0 to M1. M0-stage prostate cancer patients undergo radiation therapy techniques including external beam radiation and brachytherapy. External beam radiation techniques comprise conventional radiation therapy, three-dimensional conformal radiation therapy, and intensity-modulated radiation therapy. Permanent seed implantation is used only for the treatment of early-stage localized prostate cancer with a good prognosis. External radiation therapy is divided into three categories based on therapeutic objectives: curative, adjuvant, and palliative radiation therapy.

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What are the causes of prostate cancer?

At present, there are many factors that cause prostate cancer, but its exact etiology remains unclear. It may be related to genetic factors, gene changes, prostate gonococcal and chlamydial infections, intensity of sexual activity, and the influence of hormones. Additionally, dietary habits, long-term consumption of high-fat foods, and occupational hazards, such as excessive exposure to chromium, may also be related to the development of the disease.

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How is prostate cancer formed?

The causes of prostate cancer are not yet very clear. According to relevant data analysis, the occurrence of prostate cancer may be related to prostate gonorrhea, infections with viruses or chlamydia, as well as the intensity of sexual activity and the impact of hormones. On the other hand, a high-fat diet and some occupational factors are also somewhat related to the disease. Therefore, the formation of prostate cancer is the result of multifactorial influences including environmental and genetic factors, personal lifestyle habits, and dietary habits, all of which are significantly interconnected.

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Can prostate cancer be detected by a CT scan?

If a CT scan is performed for prostate cancer, it usually can detect the tumor in the prostate, especially an enhanced CT scan will show enhancement. However, to confirm the diagnosis, it is still necessary to perform a prostate biopsy to find cancer cells. Only with the detection of cancer cells can prostate cancer be diagnosed. Additionally, a blood test for the tumor marker PSA, which generally increases, can be used in combination with these findings for a comprehensive evaluation. The definitive diagnosis of prostate cancer requires a biopsy to find cancer cells, which is the gold standard for diagnosing prostate cancer.