Complete cure is often difficult to achieve in the middle and late stages of colorectal cancer. Of course, it is possible to control the progression of the lesion and then prolong survival. For middle and late-stage colorectal cancer, if the treatment is reasonable or effective, it is possible to survive for more than three years, five years, or even longer. Clinically, surviving more than five years without recurrence is considered a clinical cure. Of course, there is still a possibility of recurrence after five years, but the probability of recurrence will be much lower. If one can survive more than ten years, or even 20 years without recurrence, it is basically considered a cure, but regular check-ups are still necessary afterward, as it cannot be guaranteed that there will be no recurrence. For the middle and late stages of colorectal cancer, surgical treatment should be pursued whenever possible, followed by a combination of chemotherapy, radiotherapy, and targeted therapy after surgery.