Does CEA increase in throat cancer?

Written by Yan Chun

Oncology

Updated on December 17, 2024

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In the blood tests of some laryngeal cancer patients, an increase in the CEA index may be observed, but most laryngeal cancer patients do not exhibit abnormal CEA levels. This is because laryngeal cancer is a common malignant tumor in the head and neck region, and currently, there are no specific tumor markers clinically for laryngeal cancer. CEA, also known as carcinoembryonic antigen, is a tumor marker that is most often elevated in the bodies of patients with malignant tumors. Clinically, an increase in the CEA level is commonly seen in malignant tumors of the gastrointestinal tract, thoracic malignancies, malignancies in the female urogenital system, and some tumors in the male urogenital system. However, in patients with head and neck malignancies, this marker is not commonly elevated.

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After radiotherapy for laryngeal cancer, or during the process of radiotherapy, edema may occur, mainly mucosal edema in the pharyngeal region, and some patients may also experience swelling of the soft tissues in the neck. In such cases, it is recommended to visit an otolaryngology department where a laryngoscopy and routine blood tests can be conducted to help assess the severity of the condition. Generally, nebulizer therapy can be chosen. If there is an accompanying acute bacterial inflammation, antibiotics may need to be considered. Most patients will see a gradual reduction in the degree of swelling after timely medication treatment, but overall, complete recovery requires a relatively long period of time.

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Where is throat cancer likely to metastasize?

The metastasis of laryngeal cancer primarily involves local spread, mainly to the lymph nodes in zones 2, 3, and 4 of the neck. When the cancer becomes more severe, it can break through the lymphatic vessels and spread to the liver, kidneys, spleen, brain, lungs, and other related areas. Laryngeal cancer is a malignant tumor of the pharyngeal region, typically caused by long-term smoking, drinking, immunodeficiency, and cellular mutations. It commonly occurs in the vocal cords, esophagus, laryngeal ventricle, piriform sinus, base of the tongue, and epiglottis. It causes patients to feel a foreign body sensation in the throat, persistent hoarseness that progressively worsens, irritative cough, difficulty swallowing, and difficulty breathing. An examination with an electronic laryngoscope can help diagnose the condition. If an abnormal mass is found, a local biopsy is necessary. If laryngeal cancer is confirmed, related surgical treatment as well as radiotherapy or chemotherapy may be required.

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The difference between laryngeal cancer and pharyngeal cancer

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What causes throat cancer?

Throat cancer is a malignant tumor that occurs in the throat area. Its causes are not clear, but it is generally associated with long-term smoking, drinking, exposure to toxic and carcinogenic substances, as well as gastrointestinal dysfunction, acid reflux irritation, prolonged loud speaking, staying up late, fatigue, and malignant transformation of benign tumors, which lead to symptoms in the throat area. It causes persistent hoarseness in patients, and the symptoms progressively worsen. Patients may also experience a foreign body sensation in the throat, a feeling of blockage, a burning sensation, and sometimes difficulty swallowing. Patients should first go to the hospital for a detailed examination with an electronic laryngoscope, which can reveal cauliflower-like neoplasms or ulcers in any part of the throat. If such findings are present, a local biopsy is needed. If the biopsy confirms the presence of a malignant tumor, local surgery, radiotherapy, or chemotherapy is required for treatment.

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Is throat cancer prone to recurrence?

Throat cancer indeed may recur, but the specific chances and extent of recurrence vary greatly among individuals. Generally speaking, the probability of recurrence is much lower in early-stage throat cancer compared to mid and late stages. For early-stage throat cancer, surgery or radiotherapy is primarily recommended. The first two years are very critical; if there is no recurrence within two years, the likelihood of recurrence is relatively smaller. Then, the next milestone is five years; the five-year survival rate is very significant. If there is no recurrence within five years, it can generally meet the criteria for clinical cure. However, even after five years, a small portion of patients might still experience recurrence, hence the necessity to persist with long-term follow-up examinations.