Is there a cure for osteosarcoma?

Written by Na Hong Wei
Orthopedics
Updated on September 16, 2024
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Osteosarcoma is treatable, but it requires proper medical treatment. Currently, adjuvant chemotherapy significantly improves the five-year survival rate for osteosarcoma. The main treatment approach is still surgery as part of a comprehensive therapy. Specifically, the first step involves adequate preoperative chemotherapy, generally no fewer than six sessions over about eight weeks, or approximately two months. After this, patients often experience reduced pain, weight gain, improved positioning of the tumor, and a decrease in tumor size. Depending on the specific situation, a decision is made on the type of surgery to be performed—whether to amputate, preserve the limb, install a prosthetic, or use artificial bone as a replacement. Postoperative chemotherapy is usually also required to help ensure that the tumor does not recur and to increase the five-year or ten-year survival rate. Therefore, the current five-year survival rate for osteosarcoma has increased from the previous 40%-50% to about 80%. So, as long as one chooses the right hospital and the right treatment plan, and maintains confidence, osteosarcoma is usually treatable.

Other Voices

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Written by Wang Cheng Lin
Orthopedics
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What are the symptoms of osteosarcoma?

Symptoms of Osteosarcoma: The first is pain at the site of occurrence. This pain may be intermittent and not very pronounced in the early stages. As the condition progresses, the severity of the pain gradually increases, transitioning from intermittent to persistent pain; The second is the formation of a lump. You can feel a lump on the limb with your hand, and this lump is clearly tender to the touch; The third is limping, which is mainly caused by the pain in the limb; The fourth is the most common systemic symptoms. Patients with this malignant tumor will exhibit fever, weight loss, anemia, and pathological fractures. These are the main symptoms of osteosarcoma currently observed in clinical settings.

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Written by Cheng Bin
Orthopedics
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Is osteosarcoma highly malignant?

First of all, it is certain that osteosarcoma is very malignant. Once osteosarcoma is detected, it is necessary to actively prepare for surgery, rule out surgical contraindications, and then proceed with surgical treatment. During the surgery, efforts should be made to perform an extended resection, and if necessary, amputation may be required. After the surgery, the excised specimen must be sent for pathological examination to determine the pathological type. Then, based on the examination results, effective radiotherapy and chemotherapy should be chosen to control the possibility of recurrence or metastasis of osteosarcoma and to extend the patient's life as much as possible.

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Written by Guan Yu Hua
Orthopedic Surgery
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What does osteosarcoma feel like to the touch?

Osteosarcoma is a malignant tumor that consumes bone and typically shows no symptoms in its early stages. By the time symptoms are recognized, it is usually in the mid to late stages. There might be localized masses; upon discovery of such masses, a visit to the hospital for diagnostic imaging is needed. Radiological examinations reveal characteristic signs such as sunburst appearance and Codman's triangle on X-rays. Further investigation with MRI or CT scans is necessary, followed by a biopsy for confirmation. During physical examination for this type of osteosarcoma, a localized mass may be found typically around the proximal tibia or distal femur, mainly around the metaphyseal ends. The mass may be accompanied by localized heat and pain, with nocturnal pain being more pronounced. Additionally, patients might show varying degrees of weight loss. Generally, osteosarcoma can be diagnosed through physical examination and radiological findings, followed by a confirmatory biopsy. Early stages require surgical intervention. Furthermore, osteosarcomas have a high rate of early pulmonary metastasis. Using extensive chemotherapy can improve patient survival time. With rapid advancements in chemotherapy, the five-year survival rate can reach about 50%.

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Written by Na Hong Wei
Orthopedics
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Postoperative recurrence symptoms of osteosarcoma

Symptoms of recurrent osteosarcoma after surgery are generally consistent with the symptoms before the initial surgery. The main symptoms include: Firstly, localized pain, which is persistent, progressive, and does not alleviate, including pain that worsens at night. Secondly, localized swelling, which usually occurs around the surgical site if limb-sparing surgery was performed, or at the stump if amputation was done. Thirdly, the appearance of systemic cachexia and symptoms of metastasis. Systemic cachexia typically includes weight loss, anemia, fatigue, and loss of appetite. For osteosarcoma, metastasis primarily targets the lungs, where numerous cancerous shadows can be detected. Thus, the main recurrent symptoms of osteosarcoma after surgery include pain, swelling, and cachexia.

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Written by Na Hong Wei
Orthopedics
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Can osteosarcoma occur on the knee?

Can osteosarcomas grow on the knee? In fact, the locations where osteosarcomas commonly appear are indeed near the knee. There are mainly three common sites: the most prevalent is the distal end of the femur, the lower part of the thigh bone. The second most common site is the proximal end of the tibia. The third is the proximal end of the humerus. Therefore, osteosarcomas usually do grow near the knee. What are the symptoms of an osteosarcoma? The symptoms of osteosarcoma include, first, localized pain, which is a constant pain that persists, worsens, and does not alleviate, often causing night pain, and many patients do not feel pain during the day, only at night. The second symptom is a localized lump, generally spindle-shaped, with an increased skin temperature over the surface, and even distended veins due to the tumor restricting nearby joint movement. The third symptom is the appearance of cachexia or wasting syndrome throughout the body. The fourth point is that the growth of the osteosarcoma leads to erosion of the bone and eventually pathologic fractures. Thus, the likelihood of osteosarcomas appearing near the knee is very high, and many patients typically come to the hospital because of painful lumps near the knee, and then, after examination, the diagnosis is confirmed.