Osteosarcomas are generally difficult to diagnose through ultrasound. The diagnosis of osteosarcoma mainly relies on the following methods.

The first method is X-rays. X-rays can reveal a typical Codman's triangle appearing in the bone.

The second method involves using CT and MRI to detect the extent of the tumor and to see if there is extensive infiltration around it.

The third method is nuclear bone scanning. The main significance of nuclear bone scanning is to detect bone tumors early and to distinguish whether there has been any metastasis in the later stages.

The fourth method is the gold standard, which is to perform a biopsy. However, this test is invasive, requiring the cutting of tissue from the osteosarcoma for pathological examination. Of course, this method provides the highest accuracy and positive rate.