These two are distinctly different diseases. Amyotrophic lateral sclerosis (ALS) refers to a motor neuron disease, which is a degenerative neurological condition primarily affecting the upper and lower motor neurons. Patients may exhibit symptoms such as muscle atrophy, muscle twitching, general weakness, as well as potential difficulties in swallowing, articulation disorders, and atrophy of the tongue muscles. The mechanism of this disease is not very clear, symptoms progressively worsen, and there are no effective treatment methods. Neurogenic changes can be observed in electromyography. Myasthenia gravis, on the other hand, is a typical neuromuscular junction disease caused by immune dysfunction. It presents with skeletal muscle fatigue and weakness, typically worsening in the evening. Treatment with immunosuppressants has been shown to be effective.