To determine if one has syphilis, initial assessments should integrate clinical symptoms, including the presence of a chancre and syphilis rash. Subsequently, it is advised to visit an accredited hospital to undergo serological testing for syphilis, which involves the detection of both specific and non-specific antibodies of syphilis. A comprehensive evaluation of these findings can assist in diagnosing whether one is infected with syphilis. Once syphilis is confirmed, it is crucial to commence systematic and standardized treatment promptly. Generally, if both the syphilis-specific antibody test and the non-heated treponemal pallidum particle agglutination test are positive, these indicate an active syphilis infection. Treatment should be sought at a reputable medical facility, promptly utilizing penicillin for standardized treatment. If there is an allergy to penicillin, tetracycline antibiotics can be considered as an alternative.