How to administer an injection if the tetanus skin test is negative

Written by Xu Jun Hui

General Surgery

Updated on December 10, 2024

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A negative tetanus skin test indicates that there is no allergy to tetanus antitoxin, and 1500 to 3000 units of tetanus antitoxin can be directly administered via intramuscular injection in the upper arm or buttock. If the wound is heavily contaminated or the injection is not timely, the dose may be doubled or tripled at discretion, and it is also necessary to clean and dress the wound. The purpose of administering tetanus antitoxin via intramuscular injection is to prevent infection by Clostridium tetani. Therefore, patients with heavily contaminated or deep wounds must receive tetanus antitoxin treatment.

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Written by Ma Xian Shi

General Surgery

1min 26sec

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How to administer a tetanus shot: steps

First, an allergy test must be conducted. Based on the results of the allergy test, the application of tetanus antitoxin is decided. The allergy test involves drawing 0.1 ml of antitoxin serum, diluting it with 0.9 ml of isotonic saline, and then injecting 0.05 to 0.1 ml of the diluted solution intradermally on the flexor side of the forearm. An equivalent amount of isotonic saline is injected on the other forearm as a control. Observe for 15-30 minutes. If there is no nodule or resistance at the injection site, it is a negative result. Patients with a negative result can have the rest of the original liquid injected subcutaneously. If a red nodule of about one centimeter or resistance appears at the serum injection site, the allergy test is positive. In this case, a desensitization injection is needed. The desensitization injection involves diluting the required injection fluid and the antitoxin serum with isotonic saline to ten times the volume and administering it subcutaneously in divided doses. After dilution to ten times the volume, which is 10 ml, the initial dose of 1 ml is administered, followed by 2 ml, 3 ml, and 4 ml, with each injection spaced 30 minutes apart until completed.

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Written by Ma Xian Shi

General Surgery

1min 8sec

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How long does it take for tetanus to develop?

Tetanus is an acute, specific infection caused by the invasion of Clostridium tetani into a human wound, where it grows and reproduces, producing toxins. Tetanus is a Gram-positive, anaerobic, spore-forming bacillus that is widely present in the external environment. Tetanus occurs only when tetanus bacillus grows and reproduces locally in a wound and produces exotoxins, which are the cause of the disease. The toxins of tetanus include spasm toxin and hemolysin. The incubation period of tetanus generally ranges from six to ten days. In some cases, it can occur within 24 hours or take as long as 20 to 30 days, or even months, particularly following the removal of foreign bodies or shrapnel. Neonatal tetanus generally occurs seven days after umbilical cord separation, clinically also known as the "seven-day wind." Generally, the shorter the duration of the incubation period or prodromal symptoms, the more severe the symptoms and the higher the mortality rate.

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Written by Tang Da Wei

General Surgery

54sec

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Will a tetanus wound heal?

Tetanus wounds do not heal, and they contain a large amount of tetanus bacilli, which reproduce massively, leading to symptoms such as redness, pain, and even pus discharge in the affected area. Generally, these wounds cannot heal by themselves; even if the skin heals, the underlying and muscle tissues infected by tetanus can cause the skin to rupture and possibly accumulate pus. If a superficial wound is suspected to be infected with tetanus, it is necessary to promptly enlarge the wound, i.e., expand the surface wound, and rinse repeatedly with hydrogen peroxide and clean water to further kill the tetanus bacilli inside. At the same time, it is necessary to administer tetanus antitoxin, regularly observe the patient's clinical manifestations, and if necessary, administer tetanus antitoxin again after a period.

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Written by Gao Sen

General Surgery

37sec

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Tetanus 0.1ml how many units

In general, the dose of tetanus toxoid is 1500 international units per dose, approximately 1 ml per dose, and generally about 150 international units per 0.1 ml, which can be referred to the instructions. The use of tetanus toxoid should be avoided blindly and should be administered under the guidance of a physician. Additionally, wound cleaning and disinfection should be performed before administering tetanus toxoid. Furthermore, anti-infection treatment should be considered based on the contamination of the wound.

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Written by Li Jin Quan

General Surgery

38sec

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Can tetanus be cured?

Tetanus is a curable disease. It is usually caused by an infection with the tetanus bacillus, which produces a specific infection in the human body. Clinically, it is mainly manifested as muscle tension and rigidity, with the primary symptoms being difficulty opening the mouth, a sardonic smile, neck stiffness, and opisthotonos. In severe cases, it can lead to respiratory confusion, respiratory arrest, or cardiac arrest. Therefore, patients with tetanus should go to the hospital for treatment as soon as possible. With standardized and systematic treatment, the vast majority of patients can be cured.