How long does tetanus antibody last?

Written by Zhang Peng

General Surgery

Updated on March 08, 2025

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The duration of tetanus antibodies varies under two scenarios. The first is passive immunity, which is achieved through injections such as tetanus antitoxin or tetanus immunoglobulin. The duration of immunity provided by these injections is relatively short. Typically, tetanus antitoxin lasts about four days, while tetanus immunoglobulin can last up to three weeks. After this period, the levels of antibodies gradually decrease, and the body may no longer be protected. Therefore, a single application of tetanus antitoxin or immunoglobulin does not provide long-lasting immunity. The second scenario involves antibodies produced by active immunity, generally through the injection of a vaccine made from attenuated tetanus bacilli. Antibodies usually start to develop about ten days after vaccination, with levels gradually increasing over two to three months and remaining high. This type of immunity lasts up to about ten years, but it is not lifelong. Regular boosters, guided by relevant tests, are required to maintain immunity.

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Written by Zhang Peng

General Surgery

1min 7sec

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Can I breastfeed after getting a tetanus shot?

Current research indicates that lactating women are not contraindicated for tetanus vaccination; the main contraindication is allergy to the tetanus vaccine. Generally, if there are high-risk factors for tetanus infection, timely wound debridement and care should be performed, followed by early administration of passive immunization with tetanus vaccine. Generally, tetanus antitoxin can be used based on the results of a skin test. If the skin test result is strongly positive, its use should be avoided, and tetanus immunoglobulin should be chosen instead. The effective metabolic period of tetanus immunoglobulin is about three weeks. If high-risk factors for infection still exist beyond this time limit, timely enhancement of immune therapy should be considered. Regarding the tetanus vaccine, it is generally advised that the earlier it is administered, the better, as early administration can neutralize the tetanus toxin already present in the blood. However, if the tetanus toxin has already bound to nerve cells, treatment becomes relatively difficult.

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Written by Zhang Da Wei

General Surgery

55sec

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How long is a tetanus shot effective?

It is definitely better to get a tetanus shot as soon as possible, ideally within 24 hours after injury, as the chance of prevention is much higher compared to other times. Once an injury occurs, it is essential to go to a formal hospital for wound treatment, and then use disinfectant products, typically hydrogen peroxide or iodophor, to assist in disinfection. Generally, for open wounds, stitching may be necessary, but such wounds should generally not be bandaged because bandaging can lead to anaerobic bacterial infection. Since the incubation period for Clostridium tetani, the bacterium that causes tetanus, is five to seven days, an infection could potentially develop during this time. Therefore, it is advisable to get vaccinated against tetanus infection within a week. If this timeframe is exceeded, it might impact the effectiveness of the preventative measure, thus rendering it significantly less meaningful.

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Written by Xu Jun Hui

General Surgery

58sec

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Which department should I go to at the hospital for a tetanus shot?

Tetanus shots should be administered at a regular hospital in the emergency department. There are two types of tetanus injections: one that requires a skin test, called tetanus toxoid, and one that doesn't require a skin test, called tetanus immunoglobulin. It is generally recommended to get the tetanus shot within 24 hours of injury, and it is best to avoid alcohol before the injection. Drinking can cause dilation and reddening of the skin's capillaries, which can affect the results of the tetanus skin test. Tetanus is usually caused by the invasion of Clostridium tetani into the body, a type of anaerobic bacterium. Thus, for wounds that are small, deep, and heavily contaminated, such as with dirt, rust, or in cases of open fractures, anti-tetanus treatment is essential, and a tetanus shot can be administered in the hospital's emergency department.

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Written by Tang Da Wei

General Surgery

48sec

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Where is the tetanus shot given?

Tetanus injections require administration into the muscle, typically in the deltoid or gluteus maximus, which is below the patient's shoulder or on the buttocks. Before administering a tetanus shot, a skin test is usually performed. The test takes place on the inner side of the forearm, where 0.1ml of the solution is injected. Patients might experience some pain during the tetanus shot, but most can tolerate it. The tetanus shot effectively prevents tetanus infections, especially in cases where the wound is deep with a small surface area that can create anaerobic conditions conducive to the colonization and proliferation of Clostridium tetani, leading to tetanus infection. Vaccination can effectively prevent some serious diseases.

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Written by Zhang Peng

General Surgery

59sec

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How long does a tetanus shot last?

Tetanus prophylactic treatment is advised to be carried out as soon as possible, ideally within 24 hours for optimal effectiveness. However, prevention treatment can still be carried out after 24 hours, as long as the disease has not manifested. Current research does not prove that tetanus prevention is ineffective after this period. Therefore, timely and effective preventive treatment should be implemented following high-risk tetanus infection factors, choosing either tetanus antitoxin or tetanus immunoglobulin. The incubation period for tetanus infection is about a week, and as long as the disease has not manifested, choosing appropriate medication can have a preventive effect. Tetanus antitoxin and tetanus immunoglobulin have different metabolic cycles; the half-life of tetanus antitoxin is generally about three days, whereas tetanus immunoglobulin can last up to three weeks.