Can I get a tetanus shot in the evening?

Written by Liu Huan Huan
General Surgery
Updated on April 03, 2025
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If a patient has a relatively deep wound, such as reaching the subcutaneous fat layer or even more severely, the muscle layer, it is important to prevent tetanus infection. It is advised that the patient must come to the hospital for a tetanus antitoxin injection into the muscle. After an injury, the sooner the tetanus antitoxin is injected, the better, as delays can affect the effectiveness of the antitoxin. Therefore, tetanus antitoxin can also be administered at night. Generally, one should go to the emergency surgery department of the hospital for the injection, as the emergency surgery department is on duty 24 hours a day, so it is possible to receive the tetanus shot at night.

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How to administer a tetanus shot: steps

First, an allergy test must be conducted. Based on the results of the allergy test, the application of tetanus antitoxin is decided. The allergy test involves drawing 0.1 ml of antitoxin serum, diluting it with 0.9 ml of isotonic saline, and then injecting 0.05 to 0.1 ml of the diluted solution intradermally on the flexor side of the forearm. An equivalent amount of isotonic saline is injected on the other forearm as a control. Observe for 15-30 minutes. If there is no nodule or resistance at the injection site, it is a negative result. Patients with a negative result can have the rest of the original liquid injected subcutaneously. If a red nodule of about one centimeter or resistance appears at the serum injection site, the allergy test is positive. In this case, a desensitization injection is needed. The desensitization injection involves diluting the required injection fluid and the antitoxin serum with isotonic saline to ten times the volume and administering it subcutaneously in divided doses. After dilution to ten times the volume, which is 10 ml, the initial dose of 1 ml is administered, followed by 2 ml, 3 ml, and 4 ml, with each injection spaced 30 minutes apart until completed.

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How long does the tetanus shot last?

The duration of the effectiveness of a tetanus shot depends on whether tetanus antitoxin or tetanus immunoglobulin is administered following a suspected tetanus infection. Both types are forms of artificial passive immunity, providing immediate specific immunity after injection, mainly for treatment or emergency prevention. The metabolism and immune duration of these two injections vary: generally, tetanus antitoxin lasts about seven days, while tetanus immunoglobulin can last up to three weeks. Therefore, the specific duration of the effectiveness of a tetanus shot must be determined based on the individual injection circumstances. For suspected tetanus infections, it is generally advised to administer the injection as soon as possible. It's not that the injection will be ineffective if administered after a certain time, but rather that effective prevention before the onset of the disease can still be beneficial.

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What is tetanus?

Tetanus infection occurs when Clostridium tetani invades the human body through skin and mucosal membranes, producing certain neurotoxins that lead to symptoms. As Clostridium tetani is an anaerobic bacterium, it typically thrives in anaerobic environments and is often found in heavily contaminated, muddy, or rusty conditions. Therefore, if there is an infection in a wound that is deep, located in an oxygen-poor environment, or heavily contaminated with dirt or rust, or in cases of extensive open fractures, explosion injuries, etc., anti-tetanus treatment is essential. It is generally recommended to administer an injection within 24 hours of the injury, which includes tetanus toxoid that requires a skin test—this is not to be used by patients with allergies—and tetanus immunoglobulin, which does not require a skin test.

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Is the risk of tetanus high?

Tetanus occurs infrequently, but once it appears, the condition can be very severe and may lead to death if not treated promptly. Tetanus infection is mainly caused by infection with the tetanus bacillus. The tetanus bacillus is an anaerobic bacterium that exists everywhere in nature. If the wound is very deep with a small surface area, and the conditions inside the wound become anaerobic, if the tetanus bacilli inside the wound are not thoroughly cleaned, it could lead to the rapid reproduction of the tetanus bacilli, releasing tetanus toxin and causing a tetanus infection in the patient.

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What are the dietary restrictions for treating tetanus?

There are actually quite a few dietary restrictions after receiving a tetanus shot, particularly if the wound is deep, which generally necessitates the administration of a tetanus injection to achieve some preventative effects. Of course, after getting a tetanus shot, there certainly needs to be certain foods you should avoid. For instance, spicy, cold, and irritating foods should be avoided as much as possible to achieve the desired effect. Then, it's necessary to analyze the specific situation. Sometimes dietary restrictions might be just one aspect to consider. After getting a tetanus shot, it's important to rest adequately, avoid smoking, drinking alcohol, and other bad habits, which all could potentially render the tetanus bacterium ineffective. Therefore, a specific situation might require a second injection. In general, these conditions don’t have a significant impact, as long as you remember to adopt a light diet when such issues arise, which helps the wound heal better.