Tetanus infection occurs when Clostridium tetani invades the human body through skin and mucosal membranes, producing certain neurotoxins that lead to symptoms. As Clostridium tetani is an anaerobic bacterium, it typically thrives in anaerobic environments and is often found in heavily contaminated, muddy, or rusty conditions. Therefore, if there is an infection in a wound that is deep, located in an oxygen-poor environment, or heavily contaminated with dirt or rust, or in cases of extensive open fractures, explosion injuries, etc., anti-tetanus treatment is essential. It is generally recommended to administer an injection within 24 hours of the injury, which includes tetanus toxoid that requires a skin test—this is not to be used by patients with allergies—and tetanus immunoglobulin, which does not require a skin test.