Is the pertussis vaccine an inactivated vaccine?

Written by Li Jian Wu
Pulmonology
Updated on April 09, 2025
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The pertussis vaccine is not an inactivated vaccine but a live attenuated vaccine, which primarily stimulates the body to produce antibodies. Once antibodies are produced, it can effectively prevent the disease pertussis. The commonly used pertussis vaccine in clinical settings is the trivalent vaccine, also known as the DTP vaccine, which can prevent pertussis, diphtheria, and tetanus—three infectious diseases caused by pathogens. It is essential to follow medical advice and complete the vaccination schedule as prescribed to achieve prevention. After vaccination, it is crucial to observe for any complications or adverse reactions.

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Written by Li Jian Wu
Pulmonology
43sec home-news-image

Is the pertussis vaccine an inactivated vaccine?

The pertussis vaccine is not an inactivated vaccine but a live attenuated vaccine, which primarily stimulates the body to produce antibodies. Once antibodies are produced, it can effectively prevent the disease pertussis. The commonly used pertussis vaccine in clinical settings is the trivalent vaccine, also known as the DTP vaccine, which can prevent pertussis, diphtheria, and tetanus—three infectious diseases caused by pathogens. It is essential to follow medical advice and complete the vaccination schedule as prescribed to achieve prevention. After vaccination, it is crucial to observe for any complications or adverse reactions.

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Written by Li Jian Wu
Pulmonology
42sec home-news-image

How is whooping cough transmitted?

Pertussis, commonly known as whooping cough, is primarily caused by the infection of Bordetella pertussis. The main transmission routes are through the respiratory tract or via close contact, particularly in classrooms where young children are present, which can easily lead to cross-infection. The disease has an incubation period of about three to seven days, and in some cases, it can range from two to three weeks. Children under the age of five have the highest incidence rate. Clinically, vaccination is recommended for prevention. Once infected, the early stages of the disease resemble those of a common cold, with typical symptoms being paroxysmal, spasmodic coughing.

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Written by Li Jian Wu
Pulmonology
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Treatment methods for pertussis in children

The treatment methods for pertussis in children mainly involve anti-inflammatory processes, along with etiological treatment. Pertussis in children typically requires the selection of antimicrobial drugs to eradicate Bordetella pertussis. Clinically, macrolide antibiotics are primarily chosen, such as erythromycin, azithromycin, or clarithromycin. Also, depending on the nature of the cough, some central antitussive agents or cough and phlegm relieving drugs can be used to alleviate the symptoms of cough. Additionally, in the acute phase of inflammation where fever is present, antipyretic analgesics should be taken for symptomatic treatment. (Medication use should be under the guidance of a doctor.)

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Written by Li Jian Wu
Pulmonology
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Characteristics of whooping cough

Whooping cough is a respiratory infectious disease characterized by paroxysmal coughing and spasmodic cough. Some patients may exhibit a crowing sound similar to a rooster's crow or a bark-like cough. Adult patients may experience symptoms such as facial redness, runny nose, and vomiting. Diagnostic confirmation requires appropriate auxiliary tests. Once diagnosed, it is recommended to undergo isolation treatment and choose a sufficient amount of effective antibiotics to eradicate the Bordetella pertussis bacteria.

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Written by Zeng Hai Jiang
Pediatrics
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Why is whooping cough milder during the day and worse at night?

Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main symptoms are paroxysmal spasmodic coughing, a crowing inspiratory noise, with coughing occurring both during the day and at night, more significantly at night. The main reasons are as follows: first, the dry indoor air causes irritation. Second, during the night, the mucus secreted by the bronchial mucosa cannot be expelled from the body, which stimulates the bronchial nerves and triggers worsening cough symptoms. Coughing can also cause redness of the face and ears, runny nose, nausea, and vomiting.