Pertussis encephalopathy typically presents with persistent high fever, projectile vomiting, nausea, and severe headaches, which are indicators of increased intracranial pressure. It is necessary to conduct timely auxiliary examinations such as cerebrospinal fluid tests and cranial MRI for diagnosis. In conjunction with clinical symptoms, medications to alleviate cerebral edema and reduce intracranial pressure should be chosen for symptomatic treatment. Typically, corticosteroids are needed during the acute phase, along with mannitol, sedatives, and other symptomatic treatments. Additionally, antibiotics should be used to eliminate the Bordetella pertussis bacterium, the pathogen responsible for the condition.