Scrotal eczema is a type of allergic disease, which due to its unique location of onset, requires special attention in the selection of topical medications while undergoing anti-allergic treatment. In terms of diet, it is necessary to avoid spicy and irritating foods, drink more water, and consume plenty of fresh vegetables and fruits. Oral administration of levocetirizine tablets and moisturizing anti-itch capsules, total paeony glycoside capsules, and other medications are used. On top of basic skin care, non-steroidal medications such as pimecrolimus cream and compound heparin sodium cream should be applied to the affected areas. Avoid excessive scratching and washing with hot water, and wear loose cotton underwear. Eczema is a polygenic-related hypersensitivity disease with complex triggers and symptoms that tend to recur. It is not easy to cure completely, requiring comprehensive management and patience. Treatment should not be rushed and must be conducted under medical guidance.