Can severe cirrhosis be cured?

Written by Si Li Li
Gastroenterology
Updated on December 11, 2024
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Severe cirrhosis is understood to refer to the decompensated stage of cirrhosis, which is the later stage of the condition, primarily characterized by the hardening of the liver.

Additionally, it presents a series of bodily complications such as ascites, as well as esophageal and gastric varices caused by portal hypertension. Sometimes, because of these varices, accidental rupture can occur during eating, leading to severe bleeding, which is a major upper gastrointestinal hemorrhage — a very dangerous complication. If this bleeding is not controlled, it can become life-threatening. Moreover, the skin may display spider nevi, and palmar erythema can appear on the hands; these are common manifestations and complications during the decompensated phase of cirrhosis.

Thus, cirrhosis is not curable. Treatment focuses on symptomatic relief to minimize discomfort caused by the symptoms, but the disease itself cannot be cured.

Other Voices

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Is fatty liver pain indicative of liver cirrhosis?

Pain from fatty liver does not necessarily mean that the patient has progressed to cirrhosis. To determine whether it is due to cirrhosis, imaging tests, assessments of liver fibrosis through four specific tests, or measuring the liver's transient elastography should be conducted. It is also necessary to consider the patient's clinical symptoms and physical examinations. Pain in the liver area due to fatty liver might be caused by an enlarged liver after fat accumulation, which can irritate the liver capsule and cause pain. This requires a specific analysis based on the individual's situation. Treatment for fatty liver should actively involve abstaining from alcohol, reducing blood lipids, and engaging in appropriate exercise.

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The difference between fatty liver and liver cirrhosis

Fatty liver is shown through ultrasound as having an increased and finely detailed echo in the liver, which is completely different from liver cirrhosis. Liver cirrhosis is generally caused by the progression of chronic hepatitis, commonly seen in hepatitis B-related cirrhosis, hepatitis C-related cirrhosis, and alcoholic cirrhosis. Cirrhosis resulting from drug-induced liver damage or from severe fatty liver is relatively rare in clinical practice. Therefore, we should not panic. Once diagnosed with fatty liver, it can be reversed through proper diet and reasonable exercise, and its progression to liver cirrhosis can be prevented. So, everyone, there is no need to rush or panic.

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Written by Zhang Jian Kang
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Symptoms of decompensated cirrhosis due to hepatitis B

Hepatitis B virus infection repeatedly leads to severe damage to the liver. If chronic hepatitis is not actively controlled, cirrhosis may occur. A symptom of decompensated cirrhosis mainly manifests as ascites, gastrointestinal bleeding, portal hypertension, and some people exhibit symptoms of hepatic encephalopathy. The presence of these complications indicates that the patient has reached the stage of decompensated cirrhosis. Patients in this stage often exhibit distinct jaundice, dark urine, abdominal distension after eating, and the presence of ascites with a positive shifting dullness. Additionally, some patients may experience vomiting blood, black stools, liver coma, and other related symptoms. Once these symptoms appear, it indicates that the prognosis for the patient is relatively poor.

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Written by Huang Ya Juan
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Early symptoms of cirrhosis

Liver cirrhosis is generally divided into compensated and decompensated stages: The compensated stage is actually an early stage of liver cirrhosis. During this stage, most patients do not show symptoms, or they may experience some mild symptoms such as abdominal discomfort, fatigue, loss of appetite, abdominal bloating, indigestion, diarrhea, etc. Decompensated stage: Early stages often present with fatigue and weakness, and later stages can include weight loss, loss of appetite, aversion to oily foods, abdominal bloating, diarrhea, fever, etc.; The liver is the only site of albumin synthesis, and during cirrhosis, reduced serum albumin can cause edema and ascites; the liver synthesizes most clotting factors, and cirrhosis can lead to coagulation disorders, clinically manifesting as gum bleeding, skin bruising, and nosebleeds; During cirrhosis, there can also be metabolic disorders of bilirubin and bile acids, leading to jaundice; Cirrhosis can also cause hormonal metabolic abnormalities, especially in patients with alcoholic cirrhosis, who may exhibit many characteristics of male dysfunction, including impotence, erectile dysfunction, testicular atrophy, loss of body hair and muscle mass, feminization, etc. Female patients may experience cessation or reduction of menstruation, excessive menstruation, infertility, etc.; Both male and female patients can develop osteoporosis, leading to spontaneous fractures.

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Why does cirrhosis cause increasing weight loss and what can be done about it?

The reason why patients with cirrhosis are becoming thinner might be due to the decreased protein synthesis function of the liver after cirrhosis, leading to progressively lesser protein in the body, which results in the patient becoming thinner. It could also be because cirrhosis leads to poor digestion and absorption in patients, thereby reducing their absorption capacity and causing them to lose weight. Under these circumstances, some medications can be used for treatment, such as the infusion of albumin to supplement plasma proteins in the body. It is also important to actively treat the underlying cause of cirrhosis. For example, in the case of alcoholic cirrhosis, active efforts to abstain from alcohol and rehabilitative treatment are necessary. If the cirrhosis is caused by chronic hepatitis B virus infection, antiviral treatment should be administered.