The primary reason that premature ovarian failure leads to infertility is due to the decline in ovarian function it causes. Reduced ovarian function results in insufficient secretion of estrogen levels within the body. Consequently, the follicles on the ovaries do not develop and mature, and without mature egg cells, the sperm and egg cannot meet, which leads to infertility. Additionally, women with premature ovarian failure experience low hormone levels that prevent changes in the uterine lining, making it unsuitable for a fertilized egg to implant in the uterine cavity, which also causes infertility. Premature ovarian failure in women often leads to infertility. Therefore, it is difficult for women with this condition to conceive. If childbearing is desired, after treatment to regulate menstruation, it may be necessary to use assisted reproductive technologies such as in vitro fertilization to achieve pregnancy.