Causes of recurrent neonatal jaundice

Written by Li Jiao Yan
Neonatology
Updated on January 29, 2025
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Neonatal jaundice is one of the common symptoms during the newborn period, especially in early newborns. It can be a symptom that appears in the normal development process, or it may be a manifestation of certain diseases. Generally, neonatal jaundice is divided into physiological jaundice and pathological jaundice. Typically, physiological jaundice gradually increases to a certain level and then subsides, and does not recur. If the jaundice recurs, or if it significantly increases after decreasing, or reappears after subsiding, it is definitely pathological jaundice. Pathological jaundice has many possible causes, commonly including infections, hemolysis, or other genetic metabolic diseases, or some red blood cell disorders, all of which can affect the recurrence of jaundice. Therefore, if the jaundice recurs, it is advisable to visit a hospital. A neonatologist will conduct relevant examinations based on the baby's condition to confirm if it is pathological jaundice. The cause should be clearly identified for targeted treatment, followed by symptomatic treatment, and timely intervention is necessary.

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Written by Li Jiao Yan
Neonatology
1min 37sec home-news-image

normal values of neonatal jaundice

Neonatal jaundice is the most common phenomenon in the neonatal period, generally divided into physiological jaundice and pathological jaundice. If the baby's values are within the normal range, it may be physiological jaundice, which does not require special intervention and will resolve on its own. Typically, normal physiological jaundice appears 2-3 days after birth, peaks around 4-5 days, begins to lessen about a week later, and resolves within two weeks, generally occurring in full-term infants born after 37 weeks. It's advisable for babies to have their jaundice monitored daily within the first two weeks, especially during the peak period, from 2-3 days to about a week or around ten days, when jaundice monitoring should be more frequent. Normally, it's best if the bilirubin levels in newborns do not exceed 6 mg/dL in the first 24 hours, 9 mg/dL within 24-48 hours, 12 mg/dL within 48-72 hours, and 15 mg/dL after 72 hours. These values are generally considered acceptable. Additionally, jaundice progression should not be too rapid; if bilirubin levels rise more than 5 mg/dL within 24 hours, it indicates too rapid an increase in jaundice. In such cases, it is also necessary to go to the hospital, where a neonatal doctor should assess the baby and decide if special treatment intervention is needed.

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Written by Li Jiao Yan
Neonatology
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What is considered high for neonatal jaundice?

Neonatal jaundice is common during the neonatal period and can be divided into physiological jaundice and pathological jaundice. Physiological jaundice does not require intervention or treatment, and the baby's condition is generally okay. For physiological jaundice, the bilirubin level typically does not exceed 6 within the first 24 hours after birth, then not exceeding 9 from 24 to 48 hours, not exceeding 12 from 48 to 72 hours, and not exceeding 15 after 72 hours. If the monitored bilirubin levels exceed these ranges, there may be pathological jaundice, indicating abnormally high levels.

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Written by Li Jiao Yan
Neonatology
1min 21sec home-news-image

Causes of recurrent neonatal jaundice

Neonatal jaundice is one of the common symptoms during the newborn period, especially in early newborns. It can be a symptom that appears in the normal development process, or it may be a manifestation of certain diseases. Generally, neonatal jaundice is divided into physiological jaundice and pathological jaundice. Typically, physiological jaundice gradually increases to a certain level and then subsides, and does not recur. If the jaundice recurs, or if it significantly increases after decreasing, or reappears after subsiding, it is definitely pathological jaundice. Pathological jaundice has many possible causes, commonly including infections, hemolysis, or other genetic metabolic diseases, or some red blood cell disorders, all of which can affect the recurrence of jaundice. Therefore, if the jaundice recurs, it is advisable to visit a hospital. A neonatologist will conduct relevant examinations based on the baby's condition to confirm if it is pathological jaundice. The cause should be clearly identified for targeted treatment, followed by symptomatic treatment, and timely intervention is necessary.

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Written by Li Jiao Yan
Neonatology
1min 6sec home-news-image

How to care for neonatal jaundice

Neonatal jaundice is generally divided into physiological and pathological jaundice. Physiological jaundice usually does not require special intervention. During the peak period of jaundice, it is important to pay attention to feeding the baby. Strengthening feeding and encouraging the baby to defecate and urinate more can help reduce the jaundice. On the other hand, if the baby has pathological jaundice, it is advised to visit a hospital. A neonatal specialist will carefully examine the baby to determine whether special treatment is needed. Pathological jaundice is often just one symptom of a disease and there may be other pathological factors involved. Care at home for babies with jaundice should include careful feeding to prevent choking, monitoring bowel movements and urination, attending to buttock care, and observing the baby's mental state, reactions during feeding, and monitoring their temperature. Parents of babies with pathological jaundice should seek timely treatment and intervention from a doctor based on the baby's condition.

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Written by Li Jiao Yan
Neonatology
2min 14sec home-news-image

Causes of neonatal jaundice

Neonatal jaundice is generally divided into physiological jaundice and pathological jaundice. Physiological jaundice is usually considered a normal phenomenon, where the baby's jaundice can naturally recede without much impact on the baby. If it is pathological jaundice, it means that the jaundice level is high, indicating a pathological condition. Pathological jaundice can be further divided into several types, the most common being elevated direct bilirubin and elevated indirect bilirubin, each with different causes. Common causes of jaundice include increased indirect bilirubin due to infections, hemolysis, and mother-infant blood type incompatibility, such as ABO incompatibility where the mother is type O and the baby is not, or the mother has HR-negative blood and the baby has HR-positive blood. Other factors include reduced thyroid function, enzyme deficiencies such as G6PD deficiency, various types of bleeding like gastrointestinal bleeding, intracranial bleeding, or asphyxia at birth. Conditions like hypoxia or acidosis in the baby can also lead to increased jaundice. Additionally, liver function damage due to viral infections like hepatitis B, cytomegalovirus, and other infectious diseases such as syphilis, as well as other viruses like rubella virus and herpes virus can elevate jaundice levels. Developmental abnormalities of the biliary tract, commonly biliary atresia or congenital bile duct dilation, can cause elevated conjugated bilirubin levels. The causes of jaundice are complex, and some causes might remain unidentified. However, if the baby's general condition is good and the jaundice is manageable, it generally does not affect the baby. If jaundice levels are high, it is advised to visit a hospital where doctors can conduct relevant tests based on the baby's specific condition to determine if treatment is needed.