Can colitis cause anal fistula?

Written by Si Li Li
Gastroenterology
Updated on April 17, 2025
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If it is chronic colitis, it is possible to cause anal fistulas. Most patients with chronic colitis have symptoms of unformed stools and loose feces. Some feces, which are relatively thin, tend to accumulate in the anal crypts, leading to infection of the anal glands in these areas. The inflammation then spreads to the normal soft tissues around the anus, including subcutaneous tissues, forming perianal abscesses. If a perianal abscess ruptures or is surgically incised to release pus, the external opening and the pus cavity gradually heal and narrow, thus forming an anal fistula. If chronic colitis is diagnosed, it should be promptly diagnosed and treated to prevent the formation of anal fistula.

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Written by Chen Tian Jing
Colorectal Surgery
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Do anal fistulas need surgery even if there are no symptoms?

After the formation of an anal fistula, it does not always lead to acute episodes over a long period. Acute episodes of an anal fistula, causing infectious symptoms, occur only when there is a severe localized damp-heat condition. Therefore, the symptoms of an anal fistula are intermittent. The absence of symptoms does not mean that the anal fistula is completely cured or will not recur. Therefore, if an anal fistula is diagnosed, it is necessary to undergo surgical treatment as soon as possible to avoid repeated episodes due to lack of active treatment. Long-term repeated episodes of an anal fistula can lead to thickening of the fistula wall and an increase in branching. Even if an anal fistula is not actively treated over many years, it may even induce carcinogenesis in the local fistula wall.

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Written by Chen Tian Jing
Colorectal Surgery
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What should be paid attention to for anal fistula?

Patients with anal fistula, as there is an external opening in the anal region and intermittent thick secretion from this opening, should first ensure to keep the perianal area clean. It is recommended to change underwear daily and to cleanse the area after bowel movements with saline or hemorrhoid wash, and to conduct fumigation and hot compresses around the perianal area and the external opening to prevent irritation and even sharp pain caused by residual feces and secretions. Furthermore, during acute episodes of anal fistula, mupirocin ointment can be applied around the external opening for anti-inflammatory treatment. The definitive surgery for anal fistula primarily involves fistulotomy with seton placement. Without surgery, an anal fistula cannot be completely cured and may lead to worsened conditions such as thickening of the fistula wall or increased branching of the fistula channels.

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Written by Yang Dong
Colorectal Surgery Department
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What are the symptoms of an anal fistula?

Anal fistula is one of the common diseases in proctology. The most typical symptom of anal fistula is recurrent anal induration, accompanied by swelling, pain, and pus discharge, often with a ruptured external opening. During the quiescent phase, a hard cord can be felt leading from the ruptured external opening to the inside of the anus; during the acute inflammatory phase or abscess phase, pressing may cause pus to ooze from the ruptured opening.

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Written by Chen Tian Jing
Colorectal Surgery
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How to deal with the internal opening of an anal fistula?

The internal opening of an anal fistula is generally located at the site of inflammation in the anal crypt. The primary reason for the formation of an anal fistula is the repeated outbreaks at the anal crypt, which lead to further infection and the formation of a perianal abscess. When the abscess cavity ruptures, it forms an external opening and the anal fistula. Surgical treatment is required for the internal opening of an anal fistula, generally involving a seton procedure that threads a line through the internal opening and part of the sphincter muscle, gradually cutting and draining the area slowly. If the inflammation at the internal opening is significant, it may also be necessary to excise part of the infected site in the anal crypt. Post-surgery care of the internal opening of an anal fistula primarily involves dressing changes, requiring daily thorough disinfection of the local area, ensuring clear drainage, to allow the granulation tissue at the internal opening to grow freshly, and to slowly heal the wound without infection. (Medication should be taken under the guidance of a doctor.)

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Symptoms of cancerous transformation in anal fistula

The vast majority of anal fistulas do not undergo malignant transformation. However, there is a possibility of cancerous changes if an anal fistula that has repeatedly recurred over a long period is not treated aggressively, or if the inflammation of the fistula tract is severe. When an anal fistula undergoes malignant transformation, the secretion from the local fistula tract increases and is accompanied by a foul smell, and there may even be ulceration of the local fistula tract mucosa. Further surgical procedures, such as fistulotomy with seton placement, are required, and the excised fistula tract suspected of high-grade malignant transformation should be sent for pathological examination. If malignant transformation is confirmed, further pelvic MRI examinations are necessary to determine whether there is local and surrounding lymph node metastasis.