Neurodermatitis, also known as chronic simple lichen, is a common chronic inflammatory skin disease characterized by paroxysmal severe itching and lichenoid changes in the skin. Its causes may be related to various internal and external factors such as neuropsychiatric factors, gastrointestinal dysfunction, endocrine disorders, diet, and local skin irritation. Clinically, we often combine the application of topical medications with oral systemic medications. Commonly used oral medications include antihistamines, calcium supplements, vitamin C, and can also be combined with the use of glutathione vitamin B1, vitamin B12, and complex vitamin B, etc. If sleep is affected, sedative hypnotics can be added before bedtime, commonly including doxepin and diazepam. For extensive skin lesions, oral administration of Tripterygium wilfordii polyglycoside tablets can be combined.