Neurodermatitis, also called chronic simple lichen, is a common chronic inflammatory skin disease characterized by episodic severe itching and lichenoid skin changes. Its causes may be related to numerous internal and external factors, including neuropsychiatric factors, gastrointestinal dysfunction, endocrine disorders, diet, and local skin irritation. It frequently occurs in the neck, elbows, knees, sacral region, inner thighs, perineum, and around the anus. What should be done if neurodermatitis occurs on the face? First, it is crucial to avoid irritations such as scratching and rubbing as much as possible, understanding that scratching is a primary cause and aggravating factor. Second, it is advisable to choose milder topical medications for treatment, such as moisturizing and anti-itch ointments, herbal ointments, and tar-based ointments, while minimizing the use of corticosteroid ointments. Third, if the condition is severe, oral antihistamines and calcium supplements can be considered.