How is liver cancer diagnosed?

Written by Liu Liang
Oncology
Updated on September 11, 2024
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In clinical practice, if a patient has a history of chronic hepatitis B and imaging tests, such as an enhanced CT or MRI of the liver, suggest a radiological appearance of liver cancer, combined with an AFP level greater than 400 persisting for four weeks, these conditions can support a clinical diagnosis of liver cancer. However, for a confirmed diagnosis, a liver biopsy guided by ultrasound or CT must be performed. The definitive diagnosis of liver cancer relies on identifying cancer cells through pathological examination.

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Written by Sun Wei
Surgical Oncology
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Which is more treatable, primary liver cancer or metastatic liver cancer?

Primary liver cancer refers to malignant tumors that originate in the liver, while metastatic liver cancer refers to malignant tumors from other parts of the body that have spread to the liver. As to which is easier to treat, it is generally difficult to determine and depends on the control of the primary lesion in cases of metastatic liver cancer; both might be challenging to treat. However, if the lesion in primary liver cancer is relatively small, there may still be an opportunity for surgical treatment. In general, metastatic liver cancer is not amenable to curative surgery because the primary lesion also requires treatment. But in terms of the rate of progression or severity, metastatic liver cancer might progress more slowly, while primary liver cancer generally progresses quite rapidly, making it also very difficult to treat.

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Written by Wang Chun Mei
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Is increased lung markings related to liver cancer?

Increased pulmonary markings are clinically associated with many inducing factors, but they are not directly related to liver cancer. It's important to understand that liver cancer involves the presence of cancer cells in the liver, while increased pulmonary markings are radiographic signs observed during lung imaging examinations. Clinically, there are many factors that can lead to increased pulmonary markings, but liver cancer does not cause this condition. Typically, increased pulmonary markings may be due to excessive obesity, long-term smoking, or the presence of inflammatory lesions in the lungs, all of which can cause varying degrees of increased pulmonary markings.

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Early symptoms of primary liver cancer

Primary liver cancer often shows no obvious symptoms in its early stages. It may present symptoms similar to indigestion, hepatitis, etc. For example, there might be slight discomfort or pain in the upper right abdomen, aversion to oil, or loss of appetite. Generally, regular health check-ups are needed, including imaging studies of the liver such as ultrasound, CT, or MRI. Liver function tests and tumor markers such as alpha-fetoprotein (AFP) should also be performed. In most cases of primary liver cancer, AFP levels will be elevated. Combined with imaging studies, a preliminary diagnosis can be made. A definitive diagnosis requires liver biopsy or confirmation through pathology after surgery.

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and secondary liver cancer.

Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.

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How to rule out liver cancer when experiencing right shoulder pain?

Some liver cancer patients may experience abdominal pain that radiates to the shoulder and back, resulting in right shoulder pain. Therefore, when a patient presents with right shoulder pain, to rule out the possibility of liver cancer, some laboratory tests or radiological examinations can be conducted, and if necessary, histopathological examinations can also be performed. If hematological examination does not show an abnormal increase in AFP levels, and radiological examinations do not reveal any abnormal liver conditions such as large masses, nodular tumors, or diffuse liver lesions, and there is no history of hepatitis or cirrhosis, it is generally possible to rule out right shoulder pain caused by liver cancer. To determine the exact cause of the pain, examinations such as X-rays of the right shoulder, CT scans, and if necessary, MRI or bone scans can be conducted to exclude right shoulder pain caused by liver cancer lesions.