The difference between primary liver cancer and secondary liver cancer.

Written by Sun Wei
Surgical Oncology
Updated on September 16, 2024
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Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.

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Can gallbladder stones turn into liver cancer?

Long-term pathological changes from hepatobiliary calculi can lead to liver cancer. Hepatobiliary calculi generally refer to intrahepatic bile duct stones. When these stones grow in a single duct and gradually increase in number and size, they can cause obstruction of the bile duct. Obstruction of the bile duct subsequently leads to cholangitis, which involves repeated inflammatory irritation. This, in turn, can cause malignant transformation of the bile duct cells. Following this transformation, a tumor forms, which can develop into cholangiocellular carcinoma, a type of liver cancer. Therefore, if intrahepatic bile duct stones cause long-term inflammatory stimulation, it can lead to cancerous changes and result in liver cancer. Thus, if intrahepatic bile duct stones have already caused noticeable clinical symptoms such as abdominal pain, fever, and liver function abnormalities, aggressive surgical treatment should be considered.

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Surgical Oncology
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What can people with primary liver cancer eat?

Primary liver cancer, commonly referred to as liver cancer, is a type of malignant tumor of the digestive system. As for diet, there are generally no specific prohibitions. However, it is recommended to stick to a light and easily digestible diet. High-protein foods and high-quality proteins, such as fish, eggs, and protein powder, are very good options. It is best to avoid spicy, pickled, smoked, or grilled foods, as these are not conducive to health. Also, any food that is clearly moldy should definitely be avoided. The main causes of primary liver cancer include infection with aflatoxin and contaminated drinking water, which are two main causes of primary liver cancer. Other causes, like hepatitis virus infections, are also major contributors to primary liver cancer.

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Written by Sun Wei
Surgical Oncology
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Can primary liver cancer be treated?

Primary liver cancer is also treatable. Generally, if the primary liver cancer is small and has not widely metastasized, surgical resection can be considered, mainly involving hepatectomy and lymph node dissection. Postoperative comprehensive treatment including chemotherapy and radiotherapy is also applied. For primary liver cancer, interventional chemotherapy, as well as methods like cryotherapy, microwave, and ablation can be considered to control the progression of the disease. Additionally, oral targeted therapy such as sorafenib can be used. If primary liver cancer is widely metastasized at the time of detection, there generally aren’t very effective treatment options, and the average survival period might be around six months, with poor treatment outcomes.

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and secondary liver cancer

Primary liver cancer, also commonly referred to as liver cancer, originates in the liver itself and is not transferred from other parts of the body. Secondary liver cancer occurs when the primary tumor originates in another location and then metastasizes to the liver, causing hepatic space-occupying lesions; this is referred to as secondary liver cancer. The main difference between the two types is their origin. Additionally, primary liver cancer is often solitary but may develop intrahepatic or distant metastases as the disease progresses. In cases of secondary liver cancer, multiple intrahepatic metastatic lesions may be discovered at the onset. Moreover, primary liver cancer may often display an elevated alpha-fetoprotein tumor marker, whereas this marker might be normal in secondary liver cancer.

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Can an MRI detect liver cancer?

Magnetic resonance imaging (MRI) can detect liver cancer. MRI has a high resolution for soft tissues and can multi-dimensionally present the water content and fat content in liver cancer, producing specific signals. MRI can clearly show the size, signal, shape, and the surrounding tissues of liver cancer. It can even detect small liver cancers as tiny as three millimeters and is a preferred method of imaging, more precise than CT.