Kawasaki disease sequelae

Written by Yan Xin Liang

Pediatrics

Updated on November 11, 2024

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Kawasaki disease is an autoimmune vasculitis, and since it is vasculitis, it can originate from blood vessels in various parts, including the heart, liver, kidneys, brain, and more. However, it mainly arises from the coronary arteries of the heart.

If Kawasaki disease is not effectively treated, some patients can develop coronary artery dilation and even coronary artery aneurysms. Once a coronary artery aneurysm occurs, its complication includes the risk of rupture and bleeding of the aneurysm, which can be difficult to treat if there is severe bleeding.

If there is some coronary artery dilation, it can lead to the formation of coronary artery thrombosis, which is also a complication it can cause. However, the vast majority of Kawasaki disease cases, if treated effectively, can prevent coronary artery abnormalities. Therefore, as long as the treatment is timely, most cases will not have significant lasting effects.

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Written by Li Jiao Yan

Neonatology

1min 53sec

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What is Kawasaki Disease?

Kawasaki disease was first reported in 1967 by Tomisaku Kawasaki in Japan and is also known as mucocutaneous lymph node syndrome. Approximately 15% to 20% of cases experience coronary artery damage after effective treatment. Since 1970, cases have been reported worldwide, with a higher incidence among Asians. As diagnostic capabilities improve globally, the incidence of this disease is decreasing. This disease occurs sporadically or in small epidemics and can occur in any season, most commonly affecting infants and young children, with 80% of cases occurring in children under five years of age. The cause of the disease is unclear, and the mechanism of onset is also not well understood, with the primary pathological change being systemic vasculitis. The main clinical symptoms are high fever between 39 to 40 degrees Celsius, followed by ineffectiveness of antibiotic treatment, and conjunctival congestion. Other symptoms include congested, cracked lips, diffuse congestion of the oral mucosa, indurative edema of hands and feet with emerging erythema, polymorphous skin eruptions and scarlet fever-like rash, and enlarged cervical lymph nodes, which can be unilateral or bilateral, hard and tender, but not red on the surface. There may be complications involving coronary artery damage, and potential complications such as myocarditis, pericarditis, endocarditis, and arrhythmias. Additionally, there may be other associated symptoms such as interstitial pneumonia, digestive system symptoms, joint pain, and arthritis.

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Written by Yan Xin Liang

Pediatrics

1min 11sec

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How long does it take for Kawasaki disease to get better?

How long does it take for Kawasaki disease to get better? Kawasaki disease mainly presents with symptoms such as fever, conjunctival congestion, hard swelling of the hands and feet, strawberry tongue, dry and cracked lips, rashes, or superficial lymphadenopathy, along with enlarged cervical lymph nodes, etc. The main hazard of this disease is coronary artery dilation or coronary artery aneurysm formation, which is the most dangerous complication. Generally speaking, if Kawasaki disease does not lead to coronary artery aneurysms or coronary artery dilation, with effective treatment, the symptoms can be controlled in about a week. However, this disease requires long-term follow-up examinations, typically after one month, three months, six months, and a year of discharge, we must conduct follow-up inspections. It is important to be vigilant for long-term complications involving the heart and coronary arteries, so follow-up inspections of the heart echocardiogram, electrocardiogram, etc., are necessary. If there is coronary dilation, continuous monitoring is required until the coronary arteries return to normal.

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Written by Shi Ji Peng

Pediatrics

45sec

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How long does Kawasaki disease require hospitalization?

Kawasaki disease requires hospitalization and continued medication after discharge. The duration of the hospital stay is mainly determined by the child's clinical symptoms. The child can return home when the fever subsides and the dosage of aspirin is reduced, which may take about four to seven days, although this is just a general scenario. After discharge, medication must continue. If the child's coronary arteries are fine, with no dilation or lesions, a low dose of aspirin can be taken for about two months. If there are issues with the coronary arteries, aspirin must be continuously taken until the dilation resolves before stopping the aspirin, so this period can be quite long.

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Written by Li Jiao Yan

Neonatology

54sec

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Does Kawasaki disease affect lifespan?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear pathogenesis. Its pathological changes primarily involve a systemic circulatory disease characterized by vasculitis. A severe complication can lead to cardiac lesions. Generally, Kawasaki disease is self-limiting and most cases have a good prognosis. However, if Kawasaki disease is not effectively treated and results in associated coronary artery aneurysms or large artery aneurysms, it could lead to acquired heart disease. Such cardiac issues could potentially affect cardiac function later on. This might impact lifespan, but if Kawasaki disease is treated aggressively and effectively, the prognosis is good and the impact on future health is minimal.

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Written by Yan Xin Liang

Pediatrics

51sec

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How long does Kawasaki disease require hospitalization?

Kawasaki disease is an autoimmune vasculitis, primarily concerning because it affects the coronary arteries of the heart. Without effective treatment, some cases can lead to coronary artery dilation and even the formation of coronary artery aneurysms. Therefore, hospitalization is generally recommended during the acute phase of Kawasaki disease. During hospitalization, treatment typically involves the use of intravenous immunoglobulin and aspirin. After treatment with intravenous immunoglobulin, the body temperature generally begins to decrease gradually. Once the body temperature has stabilized for about three days and there are no complications, the patient can usually be discharged, so most hospital stays last about 5-7 days. (Medication should be taken under the guidance of a doctor.)