Can Kawasaki disease be cured?

Written by Li Jiao Yan
Neonatology
Updated on September 05, 2024
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Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear pathogenesis. The primary pathological change is systemic vasculitis. It commonly affects infants and young children, with 80% of cases occurring in children under five years of age. Kawasaki disease is a self-limiting condition, and most cases have a good prognosis. However, there is a 1% to 2% chance of recurrence. If not effectively treated, 15% to 25% of cases may develop coronary artery aneurysms. These aneurysms often resolve on their own within two years after the disease, but often leave behind abnormalities such as thickening of the vessel wall and decreased elasticity. Larger aneurysms may not completely resolve and can lead to thrombosis or narrowing of the vessel. Kawasaki disease is also one of the causes of acquired heart disease in children. Therefore, Kawasaki disease should be treated promptly and effectively to prevent severe complications.

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Written by Li Jiao Yan
Neonatology
48sec home-news-image

Is IgE high in Kawasaki disease?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear pathogenesis. It is speculated that certain components of infectious sources, such as superantigens, can activate CD30 T cells and CD40 ligand expression directly by binding with T cell antigen receptor fragments without going through mononuclear macrophages. Under the induction of carrier cells, there is polyclonal activation and reduced apoptosis of B08 cells, resulting in the production of large amounts of immunoglobulins such as IgG, IgM, IgA, and IgE, and cytokines. Therefore, the IgE levels in Kawasaki disease are elevated.

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Written by Li Jiao Yan
Neonatology
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Is the spirit of Kawasaki disease good?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear cause and is generally prevalent in infants and young children, with 80% of cases occurring in children under five years old. The mechanism of the disease is also not very clear. Its main pathological presentation is systemic vasculitis, often involving the coronary arteries. The primary clinical symptoms include high fever, which is unresponsive to antibiotic treatment, conjunctival congestion, diffuse oral congestion, strawberry tongue, indurative edema of the hands and feet, and palmoplantar erythema. Additionally, it may affect the heart, leading to conditions such as pericarditis, myocarditis, endocarditis, and arrhythmias. During the acute phase of Kawasaki disease, the high fever and diffuse oral mucosal congestion can affect the child's mental state. If the heart is involved, there may be abnormalities in heart rate and heart function, which can also lead to a poor mental state. Therefore, if Kawasaki disease is confirmed, it definitely requires active treatment.

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Written by Li Jiao Yan
Neonatology
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Is Kawasaki disease easy to treat?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a self-limiting disease but is an acute systemic vasculitis commonly seen in infants and children under the age of 5. The primary clinical manifestations include non-suppurative cervical lymphadenopathy, oral mucosal lesions, conjunctival congestion, prolonged fever, polymorphous rash, and hard swelling of the hands and feet with fingertip desquamation. Cardiovascular damage is the most severe complication of Kawasaki disease and can lead to coronary artery aneurysms and coronary artery dilation. If Kawasaki disease is not treated promptly, the incidence of developing coronary artery aneurysms is 15%-25%, making Kawasaki disease one of the most common causes of acquired heart disease in infants and young children. Therefore, timely treatment of Kawasaki disease is crucial, generally involving anti-inflammatory treatment, immune support, and symptomatic management. If there is no concomitant coronary artery damage, treatment involves symptomatic management. If there is coronary artery damage, the treatment duration will be longer and regular follow-up is necessary. The course of the disease can extend over months or even years, thus treatment of Kawasaki disease needs to be tailored based on the individual's condition and clinical symptoms.

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Written by Yan Xin Liang
Pediatrics
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Kawasaki disease sequelae

Kawasaki disease is an autoimmune vasculitis, and since it is vasculitis, it can originate from blood vessels in various parts, including the heart, liver, kidneys, brain, and more. However, it mainly arises from the coronary arteries of the heart. If Kawasaki disease is not effectively treated, some patients can develop coronary artery dilation and even coronary artery aneurysms. Once a coronary artery aneurysm occurs, its complication includes the risk of rupture and bleeding of the aneurysm, which can be difficult to treat if there is severe bleeding. If there is some coronary artery dilation, it can lead to the formation of coronary artery thrombosis, which is also a complication it can cause. However, the vast majority of Kawasaki disease cases, if treated effectively, can prevent coronary artery abnormalities. Therefore, as long as the treatment is timely, most cases will not have significant lasting effects.

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Written by Shi Ji Peng
Pediatrics
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How long does Kawasaki disease require hospitalization?

Kawasaki disease requires hospitalization and continued medication after discharge. The duration of the hospital stay is mainly determined by the child's clinical symptoms. The child can return home when the fever subsides and the dosage of aspirin is reduced, which may take about four to seven days, although this is just a general scenario. After discharge, medication must continue. If the child's coronary arteries are fine, with no dilation or lesions, a low dose of aspirin can be taken for about two months. If there are issues with the coronary arteries, aspirin must be continuously taken until the dilation resolves before stopping the aspirin, so this period can be quite long.