If Helicobacter pylori is not treated properly, will it become more severe?

Written by Wu Hai Wu
Gastroenterology
Updated on November 11, 2024
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Helicobacter pylori infection, if not treated properly, does not necessarily become more severe. However, if treatment fails, it is necessary to undergo re-treatment. It is recommended to visit a hospital and consult with a qualified gastroenterologist to adjust the treatment plan. The choice of specific medications, as well as their dosages and usage, should be carried out according to medical advice. During the treatment of Helicobacter pylori infection, it is important to avoid overeating, maintain regular meal times and portions, consume easily digestible foods, and eat plenty of fresh vegetables and fruits rich in vitamins. Spicy and irritating foods should be avoided.

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Written by Huang Ya Juan
Gastroenterology
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How to eradicate Helicobacter pylori

The spontaneous clearance rate of Helicobacter pylori infection is extremely low, meaning that it is almost impossible to cure itself. If not treated medically, it may lead to a lifelong infection. Currently, the consensus both domestically and internationally on handling Helicobacter pylori is that eradication requires combination therapy with multiple drugs, categorized into triple therapy and quadruple therapy, with a treatment duration of 2 weeks. Triple therapy consists of a proton pump inhibitor (PPI) plus two antibiotics. We currently use quadruple therapy, which includes two antibiotics, a gastric mucosal protectant, and a proton pump inhibitor. The choice of these drugs is complex. Common anti-inflammatory drugs include amoxicillin, clarithromycin, metronidazole, and levofloxacin; in cases of bacterial resistance, we recommend using furazolidone or tetracycline. Specific medications should be consulted in detail with a doctor. After the treatment course, we need to assess whether the eradication was successful, with a re-examination one month after stopping the drugs. After the eradication of Helicobacter pylori, the rate of reinfection in adults is very low, but the reinfection rate in children is somewhat higher than in adults. Not everyone infected with Helicobacter pylori needs eradication; it is necessary only for those with ulcers, erosion, atrophy, or related symptoms.

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Written by Jiang Guo Ming
Gastroenterology
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What are the symptoms of Helicobacter pylori infection?

Helicobacter pylori is a pathogen produced in the stomach or oral cavity. It cannot be said that Helicobacter pylori causes any specific symptoms, rather, it is the infection of Helicobacter pylori that leads to a series of diseases presenting symptoms. Some people infected with Helicobacter pylori may not show any symptoms at all. If related diseases occur, such as gastritis or ulcers, symptoms such as acid reflux, heartburn, nausea, and vomiting may appear. Additionally, some patients, like those with refractory iron deficiency anemia or idiopathic thrombocytopenic purpura, may also have conditions associated with Helicobacter pylori infection.

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Written by Si Li Li
Gastroenterology
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How to treat Helicobacter pylori positive?

The infection rate of Helicobacter pylori in our country has already exceeded 50%, and Helicobacter pylori has been confirmed as the main cause of chronic gastritis, peptic ulcers, and even gastric cancer. If Helicobacter pylori tests positive and is accompanied by symptoms or diseases of the digestive system, eradication treatment for Helicobacter pylori is necessary. The medication involves a proton pump inhibitor, two types of antibiotics, and a bismuth agent, with a treatment period of 14 days. After the 14-day treatment, the medication should be discontinued for a month before rechecking with a carbon-14 breath test to confirm whether Helicobacter pylori has turned negative. If it has turned negative, it indicates that the eradication treatment of Helicobacter pylori is successful. After infection with Helicobacter pylori, a diet easy to digest is recommended.

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Written by Si Li Li
Gastroenterology
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Is Helicobacter pylori three pluses serious?

Three pluses for Helicobacter pylori indicate that there is an infection with Helicobacter pylori, and the level of infection is not low. Helicobacter pylori is the main cause of chronic gastritis, peptic ulcers, and even stomach cancer. If a person tests positive for Helicobacter pylori infection, and has symptoms or diseases related to the digestive system, or has a family history of stomach cancer, eradication treatment for Helicobacter pylori is necessary. The treatment involves a proton pump inhibitor plus two types of antibiotics, along with a bismuth agent, for a total of 14 days. After stopping the medication for one month, a carbon-14 breath test should be re-conducted. If the result turns negative, it means that the eradication treatment for Helicobacter pylori was successful. If it does not turn negative, remedial treatment is required.

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Written by Wang Hui Jie
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Can a gastroscopy examine Helicobacter pylori?

Can a gastroscopy detect Helicobacter pylori? Helicobacter pylori is a type of bacteria, thus it cannot be seen with the naked eye. However, recent research shows that Helicobacter pylori is closely related to certain mucosal appearances observed under endoscopy. Therefore, endoscopists can infer the infection of Helicobacter pylori based on certain mucosal appearances. However, if a patient is just testing for Helicobacter pylori infection, there is no need for a gastroscopy. We can choose some non-invasive methods such as the carbon-13 breath test, carbon-14 breath test, stool antigen test, and serological antibody test, which are commonly used detection methods. Moreover, after treatment for Helicobacter pylori, it is recommended to choose the carbon-13 or carbon-14 breath test, as they are quite accurate.