Pericardial effusion generally does not cause proteinuria. Conditions that cause proteinuria mainly include hypertension and diabetes, which are common causes of proteinuria in the elderly. Additionally, patients with glomerulonephritis may also experience proteinuria, but this is more often seen in younger people. Pericardial effusion primarily affects the heart, leading to reduced cardiac pumping and resulting in ischemia and hypoxia, which can cause symptoms such as dyspnea, fatigue, and limb edema. In cases of significant pericardial effusion, cardiac tamponade may occur, leading to a sharp drop in blood pressure, with the patient experiencing profuse sweating, cold and clammy skin, and confusion, which are signs of hypotensive shock and often require emergency pericardial fluid drainage to alleviate symptoms.