Mild mitral and tricuspid regurgitation can be seen in normal individuals. As people age, factors such as valve degeneration can lead to mild regurgitation of the mitral and tricuspid valves. This condition does not require special treatment, and generally does not lead to adverse outcomes. Of course, certain diseases that cause heart enlargement can lead to widening of the valve rings, thus causing mild regurgitation of the mitral and tricuspid valves. For disease-induced mild regurgitation of these valves, it is crucial to actively treat the underlying disease causing heart enlargement, to prevent further enlargement of the heart and worsening of the regurgitation, thereby aggravating the condition of the heart disease.