Patients with chronic renal failure can have sexual intercourse, but there are prerequisites. Since sexual activity is physically demanding and requires adequate cardiopulmonary function, patients can engage in sexual activity if they do not experience chest tightness or shortness of breath and their blood pressure is well controlled. If there are no obvious symptoms of fatigue, difficulty breathing, or chest tightness during sexual activity, there should be no significant problems. However, since the patients have chronic renal failure, it is advisable to avoid conception unless prepared for pregnancy. Pregnancy can further burden the kidneys in female patients and potentially exacerbate chronic renal failure. Male patients with chronic renal failure may be taking medications that could affect sperm quality. Therefore, contraception should be practiced unless preparations have been made.