Patients with nephrotic syndrome vary in the amount of urine they produce. Some patients have normal urine output and may not exhibit obvious symptoms of edema, but others may have reduced urine output, which can even lead to acute renal failure. Nephrotic syndrome emphasizes that the glomerular filtration barrier is damaged, resulting in a large amount of urinary protein, with a 24-hour urinary protein quantitative exceeding 3.5 grams. This situation highlights the decreased ability of the filtration barrier to retain proteins in the blood, meaning the integrity of the filtration barrier is compromised. However, the kidney's ability to excrete water and metabolic waste is not indicated by the term "nephrotic syndrome" itself, thus the patient's urine output can vary.