Can nephrotic syndrome be clinically cured?

Written by Zhou Qi
Nephrology
Updated on September 09, 2024
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Nephrotic syndrome, a disease that clinically cannot be completely cured, is a chronic illness with no concept of cure. However, with appropriate treatment plans, many patients can achieve effective relief. There are two criteria for judging treatment effectiveness: first, the patient's 24-hour urinary protein quantification is controlled below 0.5 grams, and even can be controlled below 0.3 grams. Second, the patient's 24-hour urinary protein quantification is reduced by more than half compared to the baseline value. Both scenarios indicate effective treatment, but achieving a complete cure is difficult.

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Written by Wu Ji
Nephrology
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What is nephrotic syndrome?

Nephrotic syndrome is a common manifestation of glomerular disease, caused by a variety of etiologies, with large differences in treatment response and prognosis. The pathological causes of nephrotic syndrome are diverse, with the most common types being minimal change disease, focal segmental glomerulosclerosis, mesangial proliferative nephritis, membranous nephropathy, and membranoproliferative glomerulonephritis. Nephrotic syndrome can be classified into primary and secondary types based on its cause. The diagnosis of primary nephrotic syndrome mainly depends on the exclusion of secondary nephrotic syndrome. Common causes of secondary nephrotic syndrome include diabetic nephropathy, lupus nephritis, renal amyloidosis, drug-induced nephropathy, and renal tumors.

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Written by Zhou Qi
Nephrology
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How is nephrotic syndrome diagnosed?

Nephrotic syndrome is a general term for a group of clinical symptoms. Its primary diagnostic criteria include a 24-hour urine protein quantification of greater than or equal to 3.5 grams and plasma albumin less than or equal to 30 grams per liter; these two criteria are essential for the diagnosis of nephrotic syndrome. Meeting these criteria is sufficient for the diagnosis. There are also two additional supporting diagnostic criteria for nephrotic syndrome, which include possible symptoms of edema and hyperlipidemia. These four elements are the main clinical manifestations and diagnostic criteria of nephrotic syndrome.

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Written by Zhang Hui
Nephrology
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Kidney disease syndrome is classified as what disease?

Nephrotic syndrome is a clinical subtype of chronic kidney disease. It can be diagnosed when there is significant proteinuria, hypoalbuminemia, accompanied by edema and hyperlipidemia. This represents a severe stage in the progression of kidney diseases, generally requiring treatment with steroids and immunosuppressants. Nephrotic syndrome may have complications such as thrombosis, infections, hyperlipidemia, and acute renal failure.

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Written by Zhou Qi
Nephrology
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Does nephrotic syndrome cause itchy skin?

Nephrotic syndrome generally does not cause itchy skin in patients. In patients with nephrotic syndrome, the glomerular filtration barrier is severely damaged, leading to a significant presence of urinary protein and edema, but itchy skin is a rare clinical symptom. If a patient experiences itchy skin, it is recommended to visit the dermatology department of a standard hospital. As such patients may have a disordered immune system, they are prone to various skin issues, such as allergic dermatitis and eczema, which might cause symptoms of itchy skin. However, these are not directly related to nephrotic syndrome.

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Written by Zhou Qi
Nephrology
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Is nephrotic syndrome prone to recurrence?

Nephrotic syndrome is characterized by more than 3.5 grams of proteinuria in 24 hours and a serum albumin concentration lower than 30 grams per liter. Treatment of this disease should be aimed at the cause, with most patients suffering from primary nephrotic syndrome related to immune dysfunction, therefore often requiring treatment with steroids. Indeed, some patients easily experience relapses; after a period of steroid treatment, proteinuria may decrease or even turn negative. However, upon cessation of the medication or during occurrences like a cold, some patients may suffer from relapses. Not all patients respond this way, as some are dependent on steroids.