Does nephrotic syndrome easily lead to cerebral infarction?

Written by Zhou Qi
Nephrology
Updated on September 08, 2024
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Nephrotic syndrome is a high-risk factor for cerebral infarction, making patients prone to strokes. This is because patients with nephrotic syndrome excrete large amounts of protein in their urine, which reduces protein concentration in the plasma and disrupts the anticoagulant fibrinolysis system, leading to an increased tendency to form blood clots. These clots are prone to develop in the veins of the lower extremities and the renal veins, and cerebral arteries in the skull are also susceptible to occlusion. Therefore, in such patients, if the plasma albumin level is very low, such as below 20 grams per liter, there is a need for routine use of anticoagulant medications.

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Written by Zhou Qi
Nephrology
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Can people with nephrotic syndrome eat strawberries?

Patients with nephrotic syndrome can eat strawberries in moderate amounts. Patients with nephrotic syndrome typically have urinary protein levels exceeding 3.5g in 24 hours, along with noticeable symptoms of edema. It is essential for these patients to control their intake of water, especially those with severe edema, as excessive water intake can further exacerbate the swelling. Additionally, patients should limit their intake of plant proteins, follow a low-salt diet, and avoid heavy consumption of oils and fatty foods. From the above perspectives, it is generally acceptable for patients with nephrotic syndrome to eat strawberries in moderation. Strawberries contain very little plant protein and will not increase urinary protein levels. Although strawberries do not contain much salt, patients with nephrotic syndrome still need to consume them in moderation due to their high water content.

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Written by Zhou Qi
Nephrology
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Does nephrotic syndrome easily lead to cerebral infarction?

Nephrotic syndrome is a high-risk factor for cerebral infarction, making patients prone to strokes. This is because patients with nephrotic syndrome excrete large amounts of protein in their urine, which reduces protein concentration in the plasma and disrupts the anticoagulant fibrinolysis system, leading to an increased tendency to form blood clots. These clots are prone to develop in the veins of the lower extremities and the renal veins, and cerebral arteries in the skull are also susceptible to occlusion. Therefore, in such patients, if the plasma albumin level is very low, such as below 20 grams per liter, there is a need for routine use of anticoagulant medications.

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Written by Zhang Hui
Nephrology
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What tests are conducted for nephrotic syndrome?

Patients with nephrotic syndrome need to complete routine urine tests, 24-hour urine protein quantification, liver and kidney function tests, routine blood tests, electrolyte panels, blood glucose tests, and lipid profiles. Additionally, it is important to determine the cause of nephrotic syndrome, excluding the possibility of nephrotic syndrome caused by immune system diseases, including tumors, vasculitis, lupus, and other diseases. These tests include rheumatoid immune panels, antinuclear antibody spectrum, anti-GBM antibodies, ANCA panel, and immunoglobulins. Moreover, these patients should undergo kidney ultrasound, tumor marker tests, and thyroid function tests.

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Written by Zhou Qi
Nephrology
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Nephrotic syndrome urine output

Patients with nephrotic syndrome vary in the amount of urine they produce. Some patients have normal urine output and may not exhibit obvious symptoms of edema, but others may have reduced urine output, which can even lead to acute renal failure. Nephrotic syndrome emphasizes that the glomerular filtration barrier is damaged, resulting in a large amount of urinary protein, with a 24-hour urinary protein quantitative exceeding 3.5 grams. This situation highlights the decreased ability of the filtration barrier to retain proteins in the blood, meaning the integrity of the filtration barrier is compromised. However, the kidney's ability to excrete water and metabolic waste is not indicated by the term "nephrotic syndrome" itself, thus the patient's urine output can vary.

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Written by Wu Ji
Nephrology
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Criteria for the diagnosis of nephrotic syndrome

The diagnostic criteria for nephrotic syndrome include massive proteinuria, with urinary protein greater than 3.5 grams/day, hypoalbuminemia, with plasma albumin less than 30 grams/liter, severe edema, and hyperlipidemia, which includes significant increases in plasma cholesterol and triglycerides. The first two criteria are essential for the diagnosis of nephrotic syndrome, while the latter two are secondary. Clinically, if the two necessary criteria are met, the diagnosis of nephrotic syndrome is established. Patients with nephrotic syndrome should undergo a renal biopsy to determine the pathological type and guide clinical treatment.