What tests are conducted for nephrotic syndrome?

Written by Zhang Hui

Nephrology

Updated on September 25, 2024

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Patients with nephrotic syndrome need to complete routine urine tests, 24-hour urine protein quantification, liver and kidney function tests, routine blood tests, electrolyte panels, blood glucose tests, and lipid profiles. Additionally, it is important to determine the cause of nephrotic syndrome, excluding the possibility of nephrotic syndrome caused by immune system diseases, including tumors, vasculitis, lupus, and other diseases. These tests include rheumatoid immune panels, antinuclear antibody spectrum, anti-GBM antibodies, ANCA panel, and immunoglobulins. Moreover, these patients should undergo kidney ultrasound, tumor marker tests, and thyroid function tests.

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Written by Zhou Qi

Nephrology

53sec

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Causes of edema in nephrotic syndrome

Edema is a diagnostic criterion for nephrotic syndrome, as well as a major clinical symptom and characteristic of the syndrome. There are several reasons why patients develop edema. First, a large amount of protein leaks out from the kidneys, causing a decrease in the concentration of plasma albumin and a decrease in the colloid osmotic pressure in the plasma, which makes it easy for water to move from inside the blood vessels to outside, causing edema. Second, patients with nephrotic syndrome have increased vascular permeability, which also makes it easy for water to enter the interstitial tissues. Among patients with nephrotic syndrome, some are prone to acute renal failure, which further decreases the kidney's ability to excrete water, and these factors together lead to the common occurrence of edema in patients.

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Written by Zhou Qi

Nephrology

57sec

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Is nephrotic syndrome hereditary?

Nephrotic syndrome is generally not hereditary. It refers to a group of clinical symptoms and manifestations. The fundamental issue in patients is the damage to the glomerular capillaries, which leads to significant proteinuria, subsequently causing edema, hyperlipidemia, and hypoalbuminemia in the plasma. The causes of this disease are classified into primary and secondary types. Primary nephrotic syndrome is related to immune system dysfunction and may involve multiple genes; therefore, the disease is not considered a clear hereditary disease, but the likelihood of offspring developing renal issues may be higher than in the general population. Secondary nephrotic syndrome is mostly related to factors such as hepatitis B infection, allergies, diabetes, etc., and these diseases are not hereditary either.

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Written by Zhang Hui

Nephrology

56sec

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What tests are conducted for nephrotic syndrome?

Patients with nephrotic syndrome need to complete routine urine tests, 24-hour urine protein quantification, liver and kidney function tests, routine blood tests, electrolyte panels, blood glucose tests, and lipid profiles. Additionally, it is important to determine the cause of nephrotic syndrome, excluding the possibility of nephrotic syndrome caused by immune system diseases, including tumors, vasculitis, lupus, and other diseases. These tests include rheumatoid immune panels, antinuclear antibody spectrum, anti-GBM antibodies, ANCA panel, and immunoglobulins. Moreover, these patients should undergo kidney ultrasound, tumor marker tests, and thyroid function tests.

home-news-image

Written by Zhou Qi

Nephrology

46sec

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Causes of vomiting in nephrotic syndrome

Patients with nephrotic syndrome may experience vomiting for several possible reasons. First, nephrotic syndrome causes severe edema in patients, including edema of the gastrointestinal tract. This state of edema may lead to reduced gastrointestinal motility and symptoms of nausea and vomiting. Furthermore, patients with nephrotic syndrome have low plasma protein levels and poor immune function, making them prone to infections. If there is an infection in the gastrointestinal tract, patients may exhibit clinical symptoms of vomiting as well as potentially experiencing diarrhea, abdominal pain, and so on. Additionally, some patients experience vomiting due to the side effects of medications used during the treatment of nephrotic syndrome.

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Written by Zhang Hui

Nephrology

30sec

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Kidney disease syndrome is classified as what disease?

Nephrotic syndrome is a clinical subtype of chronic kidney disease. It can be diagnosed when there is significant proteinuria, hypoalbuminemia, accompanied by edema and hyperlipidemia. This represents a severe stage in the progression of kidney diseases, generally requiring treatment with steroids and immunosuppressants. Nephrotic syndrome may have complications such as thrombosis, infections, hyperlipidemia, and acute renal failure.