Causes of Arteriosclerosis

Written by Zeng Wei Jie
Cardiology
Updated on September 16, 2024
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Arteriosclerosis, the most common and important type of arteriosclerosis, is characterized by thickening and hardening of the arterial walls, loss of elasticity, and narrowing of the lumen. The causes are currently considered to be related to several factors, including age and gender, with older males being more prone. Patients with abnormal blood lipids, hypertension, smokers, those with diabetes or impaired glucose tolerance, obese patients, and those with a family history are all more likely to develop arteriosclerosis. Due to the incomplete certainty of the causes, its prevention and control are also managed through multiple factors.

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Arteriosclerosis is a disease

Arteriosclerosis is a disease characterized by thickening of the arterial wall and narrowing of the arterial lumen due to plaque formation, leading to various problems. As for whether arteriosclerosis can be prevented and treated, the answer is definitely yes. This can be achieved by maintaining good lifestyle habits. Regular exercise, quitting smoking, and controlling blood pressure and blood sugar with medications under a doctor’s guidance, as well as appropriate use of statin medications, can effectively prevent and treat the onset, progression, and worsening of arteriosclerosis.

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Early symptoms of arteriosclerosis

Arteriosclerosis often has many symptoms, which mainly depend on the location of the arteriosclerosis. For example, patients with cerebral arteriosclerosis often experience dizziness, headaches, or confusion, If it is coronary arteriosclerosis, it often causes symptoms of chest tightness or shortness of breath in patients, which tend to be more obvious or worsen after activity, If it is lower limb arteriosclerosis, it often causes pain when walking, which can disappear or significantly reduce after rest.

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The difference between arteriosclerosis and atherosclerosis

Arteriosclerosis is the most common and most important among a group of vascular diseases called arteriosclerosis. The common characteristics of various arteriosclerosis include thickening, hardening, loss of elasticity, and narrowing of the arterial walls. The characteristic of arteriosclerosis is that the affected arterial lesions start from the intima, with various lesions coexisting, including local accumulation of papyraceous and complex carbohydrates, proliferation of fibrous tissue, and formation of plaques due to calcification, along with gradual degradation of the arterial media. Secondary lesions include intraplaque hemorrhage, plaque rupture, and local thrombosis formation. Modern cellular and molecular biology techniques show that arteriosclerotic lesions are characterized by migration of macrophages, proliferation of smooth muscle cells, and abundant formation of fibrous, collagen, elastic fibers, and proteoglycans as connective tissue matrices, as well as intra- and extracellular lipid accumulation. Because the lipid accumulation in the intima appears yellow and mushy, it is called arteriosclerosis. Although arteriosclerosis is only one type of arteriosclerosis, it is commonly referred to simply as arteriosclerosis due to its frequent occurrence and significant clinical relevance.

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Written by Chen Ya
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Can arteriosclerosis be cured?

Atherosclerosis can only slow down its further progression and prevent the further occurrence of conditions such as coronary heart disease, cerebral infarction, and lower limb arterial occlusion. This is because it is influenced by many factors, including both modifiable and non-modifiable risk factors. For example, modifiable factors include abnormal blood lipids, hypertension, diabetes, smoking, and overweight obesity, which we can change. However, there are also non-modifiable factors such as age, genetics, and environmental factors. As age increases, the incidence of atherosclerosis significantly rises. Its pathological changes generally begin in childhood or adolescence, with symptoms becoming more apparent as age progresses.

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How long can one live with arteriosclerosis?

Arteriosclerosis has a certain impact on survival and longevity, but it is not an absolute determinant. People with mild arteriosclerosis have fewer sudden incidents of cerebral infarction and myocardial infarction, thus they may have a longer survival period. However, if arteriosclerosis leads to myocardial infarction or cerebral infarction, it will also affect their lifespan, but there is no absolute conclusion.